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门冬氨酸钾注射液与肠外营养液的配伍稳定性考察

Investigation on the stability of potassium aspartate injection combined with the total parenteral nutrition
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摘要 目的综合考察采用门冬氨酸钾在肠外营养液中的稳定性。方法将配制好的各个处方溶液在室温及4℃下放置48 h,分别于0、4、8、12、24、28、48 h取样,观察外观并测定其p H值、渗透压及粒径分布的变化情况。结果各处方放置24 h,外观、p H值及粒径均无明显变化,溶液稳定符合标准。结论门冬氨酸钾注射液在肠外营养液中的临床使用是安全的。 Objective To investigate the stability of potassium aspartate injection combined with the total par- enteral nutrition. Methods The samples were placed at room temperature and 4 ℃, and sampled at 0,4,8, 12,24,28 and 48 h. Particle size and particle distribution( mean diameter),pH value and osmolality were measured. Results There was no significant difference in appearance, pH, osmotic pressure and particle size distribution among the groups in 24 h, the formulations were stable and all parameters in different time com- plied with the national standard. Conclusions Potassium aspartate injection in TPN was safe in clinical use.
出处 《沈阳药科大学学报》 CAS CSCD 北大核心 2015年第4期311-316,共6页 Journal of Shenyang Pharmaceutical University
关键词 门冬氨酸钾注射液 氯化钾注射液 肠外营养液 稳定性 potassium aspartate injection potassium chloride injection TPN stability
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