血脂异常患者中医证型及血清sICAM-1、sVCAM-1水平与幽门螺旋杆菌感染的相关性研究

Correlation study between the TCM syndromes of dyslipidemia,the level of serum s ICAM-1,s VCAM-1 and helicobacter pylori infection

目的研究不同中医证型的血脂异常患者与幽门螺旋杆菌(helicobacter pylori,Hp)感染的关系,以及Hp感染对血脂异常患者血清炎症因子的影响。方法对120例血脂异常患者及20例健康对照者的流行病学信息、中医证型、血脂、血清Hp特异性抗体(helicobacter pylori immunoglobulin G,Hp Ig G)、细胞间黏附分子-1(soluble intercellular adhesion molecule-1,s ICAM-1)、血管细胞黏附分子-1(soluble vascular cell adhesion molecule-1,s VCAM-1)水平进行检测,并采用非参数检验及一元线性回归的方法进行分析。结果血清Hp Ig G表达水平从高到低为肝肾阴虚组>脾肾阳虚组>阴虚阳亢组>气滞血瘀组>痰浊阻滞组>健康对照组(P<0.01)。血脂异常组各中医证型患者血清Hp Ig G表达水平均显著高于对照组(P<0.01),肝肾阴虚组患者血清Hp Ig G表达水平与痰浊阻滞组间差异具有显著统计学意义(P<0.01)。血脂异常患者血清Hp Ig G水平与s ICAM-1(r=0.236,P<0.01)、s VCAM-1(r=0.253,P<0.01)表达水平均成正相关关系。结论血脂异常患者血清Hp Ig G水平明显高于健康对照组,且不同中医证型的血脂异常患者血清Hp Ig G水平具有差异性,Hp感染可能通过参与炎性因子的激活,从而促使动脉粥样硬化的发生发展。

Objective The study aims to research the relationship between the traditional Chinese medical （TCM） syndromes of dyslipidemia patients and helicobacter pylori （Hp） infection, and the effects of Hp infection on serum inflammatory factors of patients with dyslipidemia. Methods Detect and analyzethe epidemiological information, TCM syndromes, level of serum helicobacter pylori immunoglobulin G （HpIgG） ,soluble intercellular adhesion molecule-1 （sICAM-1） and soluble vascular cell adhesion mole- cule-1 （ sIVCAM-1 ） of 120 patients with dyslipidemia and 20 healthy controls according with conditions. Use nonparametric test and unary linear regression method to analyze. Results The expression level of se- rum HpIgG in descending order is ： deficiency of liver-kidney yin group 〉 deficiency of spleen-kidney yang group 〉 yin deficiency and yang excess group 〉 qi stagnation and blood stasis group 〉 turbid-phlegm ob- structing group 〉 healthy controls group（ P 〈 0.01 ）. Level of serum HpIgG in the patients of all groups with dyslipidemia is significantly higher than healthy controls group （P 〈 0. 01 ）. What＇s more, level of serum HplgG in patients of deficiency of liver-kidney yin group has a significant difference compared with turbid- phlegm obstructing group （P 〈 0. 01 ）. The serum HpIgG level of dyslipidemia patients is positive correla- tion to the level of serum sICAM-1 （r =0. 236 ,P 〈0. 01 ） ,sVCAM-1 （r =0. 252 ,P 〈0.01 ）. Conclusion Level of serum HpIgG in the patients with dyslipidemia is significantly higher than healthy controls group. There is statistically difference among levels of serum HpIgG in different TCM syndrome groups. Helicobact- er pylori infection may drive AS by participating in activation of serum inflammatory factors.