基于自然药学观药物体系的中药药物创新相关性思考

On Chinese medicine innovation based on drug system of natural pharmacy concept

基于自然药学观药物体系构架中药药物创新思维及其顶层设计,以提高中药药物创新水平,指导中药理想药物创制。在研究中,应用药物体系基本特性表征关联分析方法确定有效物质基础,导向药物制备与质量表征关联评价。研究结果表明:基于自然药学观药物体系所构架的药物创新顶层设计及其系列创新模式,可适用于中药药物优质制备、质量精准控制与药动学特性表征,从而指导药物创新目标的实现。因此,药物体系导向中药药物创新,可更新颖、本原、精准、有效地进行中药理想药物研究,从根本上提升中药药物质量。

Based on the nature medicine concept drug system, the drug innovation and the top design of traditional Chinese medicine （ TCM） was set up,. to improve the level of drug and guid optimum drug for TCM. The method of correlation analysis on basic drug system characteristic was used for guiding drug preparation and quality evaluation. The results show that on the basis of top design and drug innovation model by nature medicine concept drug system thinking, the goal of drug innovation can be achieved through optimum drug preparation, excellent quality control and pharmacokinetic properties characterization. Therefore, TCM drugs innovation from drug system can carry out on TCM optimum drug more original, more precise and more effective, and can radically improve the quality of TCM.