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一氧化氮与神经血管单元的关联性及相关药物研究进展 被引量：6

Research Progress in Relationship between Nitric Oxide and Neurovascula Unit as well as in Related Drugs
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摘要 一氧化氮(NO)作为一种重要的信号分子,对中枢神经系统具有重要影响。神经血管单元是近年来提出的从整体上描述中枢神经系统的新概念,NO对中枢系统的作用是多层次多角度的,NO与神经血管单元这个整体及其各组成单元均密切相关。综述NO及其合成酶的功能,在中枢神经系统疾病中NO与神经血管单元的相互作用关系及以NO信号通路为靶点的相关药物研究进展。 Nitric oxide, as an important signaling molecule, plays an important role in the central nervous system. Neurovascular unit is a new concept proposed in recent years, which takes the central nervous system as a whole unit. Nitric oxide affects the central nercous system from diffierent aspects, and it is closely related with the neurovascular unit as well as main components of it. The function of nitric oxide and nitric oxide synthase, as well as the relationship between nitric oxide and neurovascular unit in the central nervous system were reviewed. Diseases in central nervous system and drug research related with nitric oxide were also discussed in this review.
作者 倪远宁 季晖 王琳娜 许昂 陈亚琼
机构地区 中国药科大学药理学教研室
出处 《药学进展》 CAS 2015年第1期5-12,共8页 Progress in Pharmaceutical Sciences
基金 国家自然科学基金(No.81373419) 高等学校博士学科点专项科研基金(No.20130096110005)
关键词 一氧化氮 一氧化氮合成酶 神经血管单元 氧化应激 血管损伤 脑卒中 阿尔茨海默病 帕金森病 nitric oxide nitric oxide synthase neurovascular unit oxidative stress vascular injury stroke Alzheimer＇s disease Parkinson＇s disease
分类号 R96 [医药卫生—药理学]
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同被引文献70

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药学进展
2015年 第1期

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