摘要
一氧化氮(NO)作为一种重要的信号分子,对中枢神经系统具有重要影响。神经血管单元是近年来提出的从整体上描述中枢神经系统的新概念,NO对中枢系统的作用是多层次多角度的,NO与神经血管单元这个整体及其各组成单元均密切相关。综述NO及其合成酶的功能,在中枢神经系统疾病中NO与神经血管单元的相互作用关系及以NO信号通路为靶点的相关药物研究进展。
Nitric oxide, as an important signaling molecule, plays an important role in the central nervous system. Neurovascular unit is a new concept proposed in recent years, which takes the central nervous system as a whole unit. Nitric oxide affects the central nercous system from diffierent aspects, and it is closely related with the neurovascular unit as well as main components of it. The function of nitric oxide and nitric oxide synthase, as well as the relationship between nitric oxide and neurovascular unit in the central nervous system were reviewed. Diseases in central nervous system and drug research related with nitric oxide were also discussed in this review.
出处
《药学进展》
CAS
2015年第1期5-12,共8页
Progress in Pharmaceutical Sciences
基金
国家自然科学基金(No.81373419)
高等学校博士学科点专项科研基金(No.20130096110005)