吡咯并[4,3,2-de]喹啉类天然产物的研究进展

Research Progress of Natural Products Based on Pyrrolo[4,3,2-de]quinoline Skeleton

吡咯并[4,3,2-de]喹啉类生物碱是从蟾蜍以及海洋生物等中提取出来的次级代谢物,具有抗寄生虫、抗病毒、抗肿瘤等多种生物活性,是一类有成药潜力的天然产物。综述部分吡咯并[4,3,2-de]喹啉类天然产物的生物活性、生物合成以及化学合成的研究进展,并对其现存问题和发展方向进行分析和展望。

Pyrrolo[4,3,2-de]quinoline alkaloids are a series of secondary metabolites which are isolated from toads, marine organisms, etc. possessing significant physiological activities of anti-parasite, antivirus, anti-tumor and so on, thus having the potential of being developed into drugs. In this papel, some recent progress on bioactivities, biosynthesis and chemosynthesis of part of these compounds are mainly reviewed. The problems and prospects of such natural products are also provided.