摘要
石墨烯及其衍生物氧化石墨烯因具有水溶性好、比表面积大、载药量高以及易于修饰等优势,近年来在生物医药领域尤其在肿瘤治疗领域的应用研究发展迅速。综述石墨烯及氧化石墨烯作为新型药物载体材料所具有的特性和生物安全性、表面修饰方式以及在肿瘤靶向递药系统中的应用,为其在生物医药领域的应用研究提供新方法和新思路。
The application of graphene and its derivative, graphene oxide（GO）, in bio-medical field, especially in the field of tumor treatment, has been developed rapidly in recent years, owing to their good solubility in water, large specific surface area, high drug-loading capacity and easy modification. The properties, biological safety and surface modification of graphene and GO as well as their application in tumor-targeted drug delivery system as new drug carrier materials were reviewed so as to provide new method and new thinking for the research on their application in bio-medieal field.
出处
《药学进展》
CAS
2015年第1期32-39,共8页
Progress in Pharmaceutical Sciences
基金
国家自然科学基金(No.81102397)
江苏省自然科学基金(No.BK2012761)
江苏省青蓝工程-中青年学术带头人培养项目(No.02432009)
中央高校基本科研业务费专项资金(No.JKPZ2013004)
天然药物活性组分与药效国家重点实验室项目(No.JKGQ201107)
关键词
石墨烯
氧化石墨烯
表面修饰
药物载体
肿瘤靶向递药
安全性
graphene
graphene oxide
surface modification
drug carrier
tumor-targeted drug delivery
safety
