选择性雌激素受体调节剂在绝经后女性中的应用研究进展

Advances in Application of Selective Estrogen Receptor Modulators in Postmenopausal Women

雷洛昔芬和泰莫西芬是人工合成雌激素受体调节剂,具有与雌激素受体的高亲和力,并且拥有在不同的靶组织可分别表现为雌激素激动剂和拮抗剂的特性,因此又被称为选择性雌激素受体调节剂,这类药物的出现为患绝经后综合征的女性病人提供了新的用药选择。着重综述雷洛昔芬和泰莫西芬等具代表性的选择性雌激素受体调节剂在绝经后女性中的应用研究进展。

Raloxifene and tamoxifen, synthetic estrogen receptor （ER） ligands with high affinity to the ER, possess target tissue-selective estrogen agonist/antagonist properties; therefore they arc called selective estrogen receptor modulators （SERMs） providing new therapeutic options for female patients with postmenopausal syndrome. The advances in application of the representative SERMs such as raloxifene and tamoxifen in postmenopausal women were reviewed emphatically.