热毒宁注射液致过敏反应分析

Analyses on Anaphylaxis Induced by ReDuNing Injection

目的:对13例热毒宁注射液致过敏反应文献进行分析,探讨其引起过敏反应的机制和特点,为临床安全合理用药提供参考。方法:对1994—2013年中国期刊全文数据库文献进行检索,对其中涉及热毒宁注射液致过敏反应的12篇文献中报道的13例病例报告进行统计与分析。结果:热毒宁注射液致过敏反应对性别无选择,10岁以下儿童发生率较高;过敏反应均发生于用药过程中,出现时间最短为用药后2分钟,最长为连续用药6天后出现,大多集中在药后30分钟内发生;过敏反应主要临床表现累及多个系统-器官,临床表现复杂多样,主要有皮肤及附件损害、呼吸系统、胃肠道系统、全身性损害、神经系统、心血管系统、口腔系统和骨骼关节系统,其中以皮肤及附件损害为主;所有病例均发现及时,立即停药,进行对症处理,治疗和预后良好,未见死亡病例报道。结论:临床医师、药师应重视热毒宁注射液所致过敏反应的发生,了解其规律和特点,加强临床检测,以减少不良反应的发生。

Objective： To analyze the 13 cases of anaphylaxis caused by Re Du Ning injection to explore its mechanism and characteristics as the clinical references of safe and reasonable medication. Methods： By searching literature in Chinese journal full-text databases from 1994 to 2013, 13 cases related to anaphylaxis of Re Du Ning injection in 12 pieces of literature were statistically analyzed. Results： There is no gender difference of anaphylaxis induced by Re Du Ning injection and the higher incidence presented in children under 10 years old; the occurrence of anaphylaxis were all during the medicating processes, the shortest was 2 minutes, the longest was 6 days and most were less than 30 minutes after medicine administration; the major clinical manifestations of anaphylaxis were involving organs of different systems, which were complexed and varied, mainly including the impairment of skins and accessories, respiratory system, gastrointestinal system, systemic damage, nervous system, cardiovascular system, oral system as well as bone and joint system, among which the skins and accessories were damaged first; since all the cases were found timely and made an immediate withdrawal and treatment according to the symptoms, the treatment effect and prognosis were good and no deadly cases were reported. Conclusion： The doctors and pharmacists should pay attention to the anaphylaxis caused by Re Du Ning injection to learn the knowledge about its regularity and character and the clinical test should be strengthened so as to prevent the occurrence of adverse reactions.