视觉诱发电位在视神经炎诊断中的应用价值

Application of visual evoked potential in diagnosis of optic neuritis

目的观察视神经炎患者的视觉诱发电位(VEP)变化情况,探索VEP对视神经炎的诊断价值。方法对36例(40眼)视神经炎患者和32例(44眼)健康自愿者行VEP检测,比较2组间的VEP差异;绘制VEP鉴别视神经炎患者和健康人群的受试者特征曲线(ROC),分析其鉴别视神经炎的准确性。结果与健康对照组相比,视神经炎患者VEP潜伏期明显延长,振幅显著降低,差异具有统计学意义(P<0.001);由ROC曲线可知,采用VEP潜伏期和振幅鉴别视神经炎患者均有一定的准确性,ROC曲线下的面积(Area)分别为0.800和0.722,差异有统计学意义(P<0.001)。结论 VEP作为一种快速、方便且无创伤性的辅助检测方法,对视神经炎的诊断有一定的准确性。

Objective To investigate the visual evoked potential（ VEP） variation in patients with optic neuritis and explore application value of VEP in diagnosis of optic neuritis. Methods 36（ 40 eyes） patients with optic neuritis and 32（ 44 eyes）health volunteers were recruited to detect their VEP. Receiver operating characteristic curve（ ROC） was designed to evaluate the VEP power in distinguishing the optic neuritis patients from healthy people. Results The average VEP latency in optic neuritis patients was significantly delayed compared to the controls（ P 〈0. 001）. In addition,diminished VEP amplitude was found in patients with optic neuritis compared with the healthy controls（ P 〈0. 001）. According to ROC curve,a certain degree accuracy was demonstrated when VEP latency was applied to diagnose the optic neuritis patients[Area（ area under ROC curve） = 0. 800,P〈 0. 001],so was VEP amplitude（ Area = 0. 722,P 〈0. 001）. Conclusion Compared to healthy controls,delayed VEP latency and diminished VEP amplitude were observed in optic neuritis patients. VEP,an auxiliary examination which was considered to be rapid,convenient and non-invasive,possesses certain degree of accuracy in diagnosing optic neuritis. More studies were desired to investigate the application of VEP in diagnosis,stage,treatment and prognosis of optic neuritis.