降钙素原检测在慢性阻塞性肺病合并肺部感染治疗中的价值(附239例分析)

Practical value of procalcitonin detection in treatment of patients with COPD combined with pulmonary infection(A Report of 239 cases)

目的通过检测慢性阻塞性肺病(COPD)合并肺部感染患者的血清降钙素原(PCT)变化,了解其指导治疗的价值。方法收集2011年1月-2013年5月共239例AECOPD患者,随机分为两组:观察组107例,检测降钙素原(PCT),对照组132例,不检测降钙素原(PCT),两组均联合检测血白细胞计数(WBC)、C-反应蛋白(CRP)、血沉(ESR),并比较其住院时间、抗生素使用天数、临床疗效。结果比较两组患者住院天数、抗生素的使用天数,差异有统计学意义(P<0.01),两组患者临床有效率(92.0%和89.0%)比较,差异无统计学意义(P>0.05),治疗后两组患者临床和实验室指标比较,差异无统计学意义(P>0.05)。结论降钙素原检测对于慢性阻塞性肺病合并肺部感染患者的治疗有一定指导意义。

[ Objective ] To explore the clinical value of serum procalcitonin （PCT） detection in guiding treatment of patients with chronic obstructive pulmonary disease （COPD） combined with pulmonary infection. [ Methods ] Totally 239 patients with acute exacerbation of chronic obstructive pulmonary disease （AECOPD） from January 2011 to May 2013 were collected and randomly divided into two groups： observation group （n = 107） in which PCT was detected, and control group （n = 132） in which PCT was not detected. Blood white cell count （WBC）, cross-reacting protein （CRP） and erythrocyte sedimentation rate （ESR） were all detected in the two groups. Length of stay, duration of antibiotics use and clinical effect were simultaneously compared in the two groups. [ Results ] There was statistical significance in length of stay, duration of antibiotics use between the two groups （P 〈 0.01）. No statistically significant difference existed in clinical effective rate （92.0% ,89.0%）, clinical and laboratorial indexes between the two groups （P 〉 0.05）. [ Conclusions ] Procalcitonin detection may be used as a guide in antibiotics application in the patients with COPD combined with pulmonary infection.