期刊文献+

ACS患者介入术围手术期口服阿托伐他汀改善预后的作用分析 被引量:4

下载PDF
导出
摘要 目的观察口服阿托伐他汀对急性冠状动脉综合征(ACS)介入治疗患者预后的影响。方法选取人医院治疗的ACS患者90例作为研究对象,均行经皮冠状动脉介入术(PCI)治疗,采用数字随机表将患者分为对照组与观察组。对照组于人院后取20mg阿托伐他汀口服,观察组入院时取80mg阿托伐他汀口服,术前2h再服40mg,术后两组均取阿托伐他汀行强化治疗,观察手术前后血清肌酸激酶同工酶(CK—MB)、血浆肌钙蛋白(cTnI)、高敏反应蛋白fhs—CRP)和血脂水平,观察不良用药反应,随访30天观察两组临床终点事件发生率。结果观察组术后CK—MB、cTnI、hs—CRP水平分别为(0.40±0.16)μg/L、(0.37±0.19)μg/L、(4.75±1.36)mg/L,均显著低于对照组,差异有统计学意义(P〈0.05)。随访30天,观察组临床终点事件发生率为8.89%,显著低于对照组的37.78%,差异有统计学意义(P〈0.05)。结论强化阿托伐他汀治疗,可降低ACS患者介入术围手术期机体炎性水平,抑制心肌损伤,有利于提高手术效果。
作者 王俊英
出处 《国际医药卫生导报》 2015年第7期947-949,共3页 International Medicine and Health Guidance News
  • 相关文献

参考文献8

二级参考文献63

  • 1中国成人血脂异常防治指南[J].中华心血管病杂志,2007,35(5):390-419. 被引量:5228
  • 2Lerman A,Holmens DR Jr,Bell MR,et al.Endothelin in coronary endothelial dysfunction and early atherosclerosis in humans[J].Circulation,1995,92(9):2426-2431.
  • 3Biasucci LM,Colizzi C,Rizzello V,et al.Role of inflam-mation in the pathogenesis of unstable coronary artery diseases[J].Scand J Clin Lab Invest Suppl,1999,230 (1):12-22.
  • 4Correia LC,Sposito AC,Lima JC,et al.Anti-inflam-matory effect of atorvastatin (80 mg) in unstable angina pectoris and non-Q-wave acute myocardial infarction[J].Am J Cardiol,2003,92(3):298-301.
  • 5Tokac M,Ozeren A,Aktan M,et al.The role of inflammation markers in triggering acute coronary events[J].Heart Vessels,2003,18 (4):171-176.
  • 6Jaster M,Schwimmbeck P,Spencker S,et al.Ran-domized comparison of platelet-leukocyte aggregates and platelet activation in blood:heparin-coated coiled wire stent implantation versus balloon angioplasty in acute myocardial infarction[J].Thromb Res,2003,112(5-6):285-289.
  • 7Stettler C, Wandel S, Allemann S, et al. Outcomes associated with drug-eluting and bare-metal stents: a collaborative network recta-analysis. Lancet, 2007,370 : 937-948.
  • 8Jones PH, Famer JA. Adjunctive intervention in myocardial infarction:the role of statin therpy . Curr Atheroscler Rep, 2008,10:142 -148.
  • 9Patti G, Pasceri V, Colonna G, et al. Atorvastatin pretreatment improves outcomes in patients with acute coronary syndromes undergoing early perculaneous coronary intervention,. results of the ARMYDA-ACS randomized trial . J Am Coll Cardiol, 2007,49: 1272-1278.
  • 10Li X,Lin C,Cui J ,et al. Effects of pravastatin on the function of dendritic cells in patients with coronary heart disease. Basic Clin Pharmacol Toxicol,2009,104: 101-106.

共引文献4984

同被引文献29

二级引证文献27

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部