摘要
目的 评价Ⅰ-Ⅲ期乳腺癌患者术后进行内乳淋巴结放疗的疗效。方法 计算机检索中国期刊全文数据库、中国生物医学文献数据库、万方数据库、Pub Med、EMBASE、Web of Science、The Cochrane Library。纳入比较乳腺癌患者术后内乳淋巴结放疗组与未放疗组的临床对照研究。按照Cochrane系统评价手册5.2质量评价标准,对纳入文献方法学进行质量评价,用Rev Man 5.2软件进行Meta分析。结果 共纳入7项研究(6 835例患者)。Meta分析结果显示,与内乳淋巴结未放疗组比较,术后内乳淋巴结放疗组在5年生存率(OR=1.08,95%CI:0.93-1.27)、10年生存率(OR=0.86,95%CI:0.55-1.35)和10年无瘤生存率(OR=1.20,95%CI:0.99-1.45)方面的差异均无统计学意义(均P〉0.05)。结论 对内乳淋巴结行放射治疗没有提高Ⅰ-Ⅲ期乳腺癌患者的生存率及无瘤生存率。
Objective To assess the efficacy and safety of postoperative radiotherapy of internal mammary nodes in stage Ⅰ-Ⅲ breast cancer with meta-analysis. Methods CNKI,CBM,Wanfang,PubMed,EMBASE,Web of Science and The Cochrane Library were searched to retrieve clinical controlled trials on postoperative radiotherapy of internal mammary nodes for patients with stage Ⅰ-Ⅲ breast cancer. Quality assessment and date extraction were done according to the Cochrane Reviewer's Handbook 5.2. Meta-analysis was performed using RevMan 5.2 software. Results Seven studies involving 6 835 patients were included in the analysis. The analysis showed that there were no differences in 5-year survival rate ( OR = 1.08,95% CI:0.93 - 1.27), 10-year survival rate ( OR = 0.86,95% CI : 0.55 - 1.35 ) and 10-year disease- free survival rate( OR = 1.20,95% CI:0.99 - 1.45 ) between patients with and without postoperative radiotherapy of internal mammary nodes ( all P 〉 0.05 ). Conclusion Internal mammary node irradiation has no advantage in overall survival and disease-free survival for patients with stage Ⅰ-Ⅲ breast cancer.
出处
《实用肿瘤杂志》
CAS
2015年第2期126-132,共7页
Journal of Practical Oncology
基金
甘肃省技术开发专项(1004TCYA006)
中国临床试验注册中心(Chi CTR TRC-13003827)