结直肠癌中SGLT-1、EGFR和HER-2蛋白的表达及意义

Expression of SGLT-1,EGFR and HER-2 in colorectal carcinoma

目的探讨钠葡萄糖转运子1(Na+/glucose cotransporter,SGLT-1)、表皮生长因子受体(epidermal growth factor receptor,EGFR)和人表皮生长因子受体-2(human epidermal growth factor receptor-2,HER-2)在结直肠癌中的表达及其意义。方法采用免疫组织化学法检测80例结直肠腺瘤组织、167例正常结直肠黏膜组织和251例结直肠癌组织中SGLT-1、EGFR和HER-2的表达,分析其与结直肠癌临床病理特征的关系。结果 SGLT-1、EGFR、HER-2蛋白在结直肠癌组织中表达阳性率分别为60.6%、65.7%和70.9%,明显高于腺瘤组织(26.3%、42.5%和43.8%)和正常黏膜组织(13.8%、21.0%和19.2%)(均P<0.05)。SGLT-1的表达与结直肠癌的分化程度和TNM分期有关(均P<0.05)。EGFR的表达与结直肠癌的TNM分期和淋巴结转移有关(均P<0.05)。HER-2的表达与结直肠癌的分化程度、TNM分期和淋巴结转移有关(均P<0.05)。结论 SGLT-1、EGFR、HER-2蛋白在结直肠癌组织中高表达,这可能与结直肠癌的早期发生、发展有关。联合检测SGLT-1、EGFR和HER-2有助于判断结直肠癌的发生及生物学行为。

Objective To explore the expression of Na^＋/glucose cotransporter （SGLT-1） ,epidermal growth factor receptor（EGFR） and human epidermal growth factor receptor 2 （HER-2） in colorectal carcinoma. Methods SGLT-1, EGFR and HER- 2 levels in 251 colorectal carcinoma tissue samples, 80 eoloreetal adenoma tissue samples and 167 normal coloreetal mucosa tissue samples were deeteeted by immunohistochemistry. Correlations between protein levels and clinical pathological characteristics of colorectal carcinoma were analyzed. Results SGLT-1 ,EGFR and HER-2 levels were higher in carcinoma tissue than those in adenoma tissue and normal colorectal tissue （60.6%, 65.7%, 70. 9% vs 26.3%, 42. 5%, 43. 8% and 13. 8%, 21. 0%, 19. 2% ; both P 〈 0.05）. SGLT-1 expression was associated with the differentiation and TNM staging of colorectal carcinoma （ both P 〈 0. 05 ）. EGFR expression was correlated with TNM staging and lymph node metastasis （ both P 〈 0.05 ）. HER-2 expression was related to differentiation, TNM staging and lymph node metastasis （all P 〈 0.05）. Conclusion High levels of SGLT-1, EGFR and HER-2 may be related to the carcinogenesis and development of colorectal carcinoma. SGLT-1, EGFR and HER-2 may help to predict the prognosis of colorectal carcinoma.