宣威肺癌的致病环境因子研究和诊治进展

Progress in the environmental risk factors, diagnosis and treatment of lung cancer in Xuanwei city, China

中国云南省宣威地区一直是全球范围内肺癌发病率和死亡率最高的地区之一。上世纪八十年代以来,国际上对该地区肺癌在流行病学、发病机制和分子生物学等方面进行了大量的研究。随着分子检测技术的进步和DNA二代测序技术的应用,有关宣威肺癌的致病环境因子和临床诊治的研究取得了更多进展。为进一步探讨这一国际热点问题,本文重点从宣威肺癌的环境风险因子、基因表达及突变、诊断和药物治疗等方面对云南宣威肺癌的研究现状进行概述,并展望第二代基因测序等生物学和信息学分析技术在宣威肺癌诊断和治疗过程中的积极作用。

The morbidity and mortality rates of lung cancer in Xuanwei city, Yunnan province, China are the highest in the global scope.Since 1980 s, the studies conducted in this region supported by international health organizations have been focused on the epidemiology, pathogenesis and molecular biology of Xuanwei lung cancer. With the development of molecular detection techniques and the application of next-generation sequencing technique, great progress has been achieved in understanding the environmental risk factors which cause this disease and the improvement of diagnostic methods and therapeutic measures in Xuanwei city. This review surveys the recent development in research of lung cancer in this area from the perspectives of environmental risks, mutation and expression of cancer-related genes, and the diagnosis and drug treatment. Moreover, the positive role of next-generation sequencing technique in diagnosis and treatment of Xuanwei lung cancer will be discussed.