自拟四物四藤汤联合来氟米特治疗类风湿关节炎疗效观察

目的:观察四物四藤汤联合来氟米特治疗类风湿关节炎疗效,并通过治疗组与观察组的对比研究,客观评价中西医结合治疗对类风湿关节炎的有效性。方法:将根据简单随机、对照的临床试验原则,选入80例符合类风湿关节炎西医诊断标准以及中医辨证符合肝肾不足型和气血两虚型证候标准的病人。将80例患者随机分为两组,其中治疗组40例,以来氟米特片10mg日两次口服;观察组40例,在治疗组基础上给予自拟四物四藤汤加减治疗,疗程为12周。以ACR20、ACR50、ACR70以及ESR、CRP评价疾病改善程度和病情活动情况。结果:1.治疗后观察组ACR50患者比例明显高于治疗组,差异有统计学意义(P<0.05);2.治疗后两组患者C-反应蛋白(CRP)、红细胞沉降率(ESR)与治疗前比较均有明显好转(P<0.05)。结论:四物四藤汤加减联合来氟米特治疗在ACR50改善方面明显优于单用来氟米特治疗,值得临床推广应用。

Objective： To observe with Siwu siteng decoction Combined with leflunomide treatment of rheumatoid arthritis , and through the comparative study of the treatment group and the observation group, an objective evaluation of the effectiveness of for rheumatoid arthritis. Methods： According to simple random, controlled clinical trial principles, elected to the 80 cases of patients who meet the diagnostic criteria for rheumatoid arthritis Western and TCM comply with liver and kidney insufficiency and blood deficiency syndrome type standards. 80 patients were randomly divided into two groups, the treatment group of 40 patients to date leflunomide tablets 10rag orally twice ; observation group, 40 patients ifl the treatment group based on the given object from the Modified Siwu siteng decoction treatment, treatment for 12 weeks . With ACR20, ACR50, ACR70 and ESR, CRP evaluate the degree of improvement in disease activity and disease . Results： After treatment, the observation group 1 patients was significantly higher than the proportion of ACR50 treatment group, the difference was statistically significant （P 〈0.05）; 2 groups of patients after treatment C- reactive protein （CRP）, erythrocyte sedimentation rate （ESR） and. before treatment were significantly improved （P 〈0.05）. Conclusion ： The Siwu siteng decoction combined leflunomide therapy was superior improvement in ACR50 leflunomide alone, worthy of clinical application.