老年椎基底动脉供血不足患者血脂水平与血管波动指数的相关性研究

Studies on the correlation between serum lipid levels and vascular volatility index in elderly vertebrobasilar insufficiency

目的:通过检测不同性别的老年椎基底动脉供血不足患者血清中血脂水平与血管波动指数特点,分析二者的相关性及与患者性别的关系。方法:收集71例老年椎基底动脉供血不足患者及50例健康对照者外周血,检测血脂水平,采用多普勒超声检查计算出血管波动指数,随后对比分析不同性别间血脂与血管波动指数的差异及二者的相关性。结果:老年椎基底动脉供血不足患者的三酰甘油、总胆固醇的水平显著升高,但在不同性别的患者中二者无明显差异(P>0.05),而血管波动指数在健康对照与老年患者间、不同性别的患者间均无显著的差异。三酰甘油、总胆固醇的水平与血管波动指数呈现正相关性(r=0.34,P=0.029;r=0.56,P=0.017);结论:本研究发现在老年椎基底供血不足患者中血脂水平在不同性别的患者中无明显差异,且血管波动指数与患者血脂水平密切相关,但对于其中的具体生物学机制有待进一步探讨。

Objective： To detect the expression level of serum lipid and vascular volatility index（WI） in elderly patients with vertebrobasilar insufficiency patients; different sexes, and then explore their relevance with gender. Method： The serums from 71 case with vertebrobasilar insufficiency patients, 50 healthy controls were collected, and the expression level of and was detected, then analysing the relationship between serum lipid and WI in elderly patients; Result： TG, TC levels were significantly increased. No difference in WI also could be observe. The positive correlation between TG, TC level and VVI were identified（r=0.34, P=0.029; r =0.56, P=-0.017）. Conclusion： The study found that no significant difference in lipid levels was in older vertebrobasilar insufficiency patients between male and female. Vascular volatility index could be related with serum lipid level. However, the accurate mechanism should be explored further.