门诊抗菌药物合理使用依从性培养

Cultivation of compliance for outpatient antibiotic rational use

目的:探讨门诊抗菌药物使用的特点,针对性采取干预措施,培养合理使用抗菌药物的依从性,建立长效工作机制。方法:随机抽取2012年和2013年门诊处方4000份,比较干预前后门诊处方抗茵药物使用率,不合理使用率和类型、抗茵药物费用等。结果:干预前后抗菌药物使用率、不合理使用率及抗茵药物费用的差异均有统计学意义(P<005)。抗菌药DDDs干预前后分别为4565和2824,下降了约40%;干预后未按PK/PD参数给药、超剂量给药、选用不当等不合理用药例数均显著下降(P<0.05)结论:通过对门诊规范使用抗茵药物依从性的培养,不合理使用抗菌药物现象得到明显遏制,未出现波动与反弹,其干预措施可形成长效工作机制。

Objective： To explore the characteristics of outpatient antibiotic use and cultivate compliance of rational use antibiotic, further to establish a long-term working mechanism through setting up a series of intervention measures. Methods： A total of 4000 prescription was randomly selected in 2012 and 2013. Different comparisons about the use of antibiotics and the cost of antibiotics were made before and after the intervention. Results： Atter the intervention measures, the clinical use rate of antibiotics, irrational use rate and the cost of antibiotics obviously cut down （P〈0.05）. The antibiotic DDDs was respectively calculated as 4565 and 2824 before and after the intervention, decreased about 40%. After the intervention measures, the cases of irrational use, including no administration according to PK/PD parameters, Super dose and wrong choose, et al, were decreased（P〈0.05）.Conclusion： The irrational use of antibiotics in our hospital was significantly improved through cultivating compliance of rational use antibiotic, and there was no rebound. These invention measures would form a long-term working mechanism.