尿β_2-微球蛋白与尿肌酐比值诊断早期肾功能损伤的临床价值

Clinical Value of Urinary β_2-Microglobulin/Creatinine Ratio in Diagnosis of Early Renal Dysfunction

目的探讨尿β2-微球蛋白与尿肌酐比值诊断早期肾功能损伤的临床价值。方法选取2013年1—12月接受治疗的142例早期肾功能损伤患者作为研究组,选取同期体检的正常志愿者86例作为对照组,对比2组患者的尿β2-微球蛋白与尿肌酐比值。结果研究组患者的尿β2-微球蛋白、血清胱抑素C以及尿肌酐含量明显高于对照组,差异具有统计学意义(P<0.05);研究组β2-微球蛋白与尿肌酐比值明显高于对照组,差异均具有统计学意义(P<0.05),2组错误判断率都很低,差异不具有统计学意义(P>0.05)。结论尿β2-微球蛋白与尿肌酐比值能够有效、快捷、准确地诊断早期肾功能损伤。

ABSTRACT:Objective To discuss the clinical value of urinaryβ2-microglobulin/creatinine ratio in the diagnosis of early renal dysfunction.Methods One hundred and forty-two patients who re-ceived treatment between January and December 2013 for early renal dysfunction were selected as the study group,and 86 normal volunteers who received physical examination during the same pe-riod as the control group.The urinary β2-microglobulin/creatinine ratio was compared between the two groups.Results Compared with control group,the levels of urinaryβ2-microglobulin,ser-um cystatin C and urinary creatinine and the β2-microglobulin/creatinine ratio significantly in-creased in study group (P <0.05).The misjudgement rate was low in both groups,and was not significantly different between the two groups (P >0.05).Conclusion Urinaryβ2-microglobulin/creatinine ratio can be used to effectively,rapidly and accurately diagnose early renal dysfunction.