超声诊断脂肪肝与血脂水平及肝功能的关系

Relationships of Ultrasonic Diagnosis of Fatty Liver Disease to Blood Lipid Levels and Liver Function

目的探讨超声定量分析脂肪肝与血脂、肝功能之间关系。方法对在永新县人民医院经超声诊断为脂肪肝的患者331例(脂肪肝组,其中轻度脂肪肝102例,中度脂肪肝136例,重度脂肪肝93例)及健康体检经超声诊断无脂肪肝的正常者200例(对照组)采集空腹静脉血3 mL,采用罗氏7600生化全自动分析仪检测测定总胆固醇(TC)、三酰甘油(TG)、丙氨酸转氨酶(LT)及氨酰转肽酶(GGT)水平。结果脂肪肝组的TC、TG、GGT、ALT水平及异常检出率明显高于对照组(P<0.05或P<0.01);重度脂肪肝患者TC、TG、GGT及ALT异常率均明显高于轻、中度脂肪肝患者,中度脂肪肝患者高于轻度脂肪肝患者(均P<0.05)。结论超声对脂肪肝分型准确,结合血脂、肝功能的异常情况对脂肪肝诊断及预后具有指导价值。

ABSTRACT:Objective To explore the relationships of ultrasonic quantitative analysis of fatty liver disease to blood lipid levels and liver function.Methods Fasting venous blood samples (3 mL)were collected from 331 patients with fatty liver disease diagnosed by ultrasound(mild in 102,moderate in 136 and severe in 93)and 200 control subjects without fatty liver disease in Yongxin People’s Hospital.Levels of total cholesterol(TC),triacylglycerol(TG),alanine amin-otransferase(ALT)and gamma-glutamyltransferase(GGT)were determined using an automated biochemistry analyzer(Roche 7600).Results Compared with control subjects,the levels and ab-normal rates of TC,TG,GGT and ALT significantly increased in patients with fatty liver disease (P <0.05 or P <0.01).Compared with patients with mild to moderate fatty liver disease,the ab-normal rates of TC,TG,GGT and ALT significantly increased in patients with severe fatty liver disease(P < 0.05).Compared with patients with mild fatty liver disease,the abnormal rates of TC,TG,GGT and ALT significantly increased in patients with moderate fatty liver disease(P <0.05).Conclusion Fatty liver disease can be classified accurately by ultrasound.The combination of ultrasonic examination and detection of blood lipid and liver function abnormalities has a guid-ing value in the diagnosis and prognosis of fatty liver disease.