摘要
目的考察热毒宁注射液与两种常用溶媒配伍后制剂中绿原酸、新绿原酸、隐绿原酸、咖啡酸、栀子苷、断氧化马钱子苷、异绿原酸A、异绿原酸B、异绿原酸C等9种成分的稳定性,为临床用药提供实验依据.方法：将热毒宁注射液分别与5%葡萄糖注射液和0.9%氯化钠注射液按50∶250的比例配伍,考察0～6 h内配伍药液中9种成分含量变化情况.结果与结论：热毒宁注射液与5%葡萄糖注射液和0.9%氯化钠注射液配伍6 h内,其中9种成分均稳定.
Objective: To investigate the compatible stability of chlorogenic acid, neochlorogenic acid,cryptochlorogenic acid, cafferic acid, geniposide, secoxyloganin, isochlorogenic acid A, isochlorogenic acid B and isochlorogenic acid C in Reduning Injection mixed with two solvents, to provide an experimental basis for clinical medicine. Methods: The changes of the nine components in Reduning injection combined with5% glucose injection or 0.9% sodium chloride injection respectively(Reduning injection : solvent=50:250)were determined by HPLC. Results and Conclusion: The 9 components were stable in 6 h after combining Reduning injection and 5% glucose injection or 0.9% sodium chloride injection.
出处
《药学与临床研究》
2015年第2期150-152,共3页
Pharmaceutical and Clinical Research
基金
国家重大新药创制项目(编号:2013ZX09402203)
