摘要
目的:评价地佐辛不良反应发生相关风险因素,为临床合理用药提供参考信息。方法:通过我院HIS收集2013年地佐辛注射液使用情况,通过国家药品不良反应监测系统收集其不良反应发生情况并对所有使用患者核实以排除不良反应漏报情况;对年龄、性别等因素采用单因素和多因素Logistic回归,逐步向前法筛选变量。结果:2013年我院地佐辛注射液使用患者3257例,发生不良反应者56例。单因素和多因素Logistic回归分析均显示具有统计学意义(P<0.05)的影响因素为:性别、肝病、科室。结论:地佐辛不良反应的发生可能与性别、肝病和科室有关。
Objective: To assess the risk factors of dezocine in order to provide reference information for the clinical rational use. Methods: Data were collected for the utilization of dezocine in 2013 through HIS; the occurrence of adverse reactions were collected through the national information system of monitoring adverse reaction and verified. The data collected were treated with univariate and multivariate analysis of variance, forward stepwise selection of variables. Results: Dezocine was used in 3257 patients in 2013, adverse reactions occurred in 56 cases. The result of univariate and multivariate analysis of variance showed that sex, departments and liver disease were the main risk factors(P<0.05). Conclusion:Adverse effects of dezocine may be associated with sex, liver disease and the department.
出处
《药学与临床研究》
2015年第2期191-193,共3页
Pharmaceutical and Clinical Research
关键词
地佐辛
不良反应
分析
Dezocine
Adverse Reactions
Analysis
