鼻咽癌放化疗后突发性聋的临床分析

Clinical analysis of sudden deafness after radiotherapy and chemotherapy in nasopharyngeal carcinoma patients

目的:探讨鼻咽癌放化疗后并发突发性聋患者的临床特点及治疗效果。方法:回顾性分析42例鼻咽癌放疗后并发突发性聋患者的临床资料,42例患者中,中度聋2例,中重度聋4例,重度聋30例,极重度聋6例;听力曲线符合中高频下降型33例,全聋型9例。均采用药物治疗及高压氧治疗。结果:痊愈2例,显效2例,有效9例,无效29例,总有效率为30.95%;伴随症状中,耳鸣30例均未缓解,耳闷10例有3例缓解,头晕或眩晕5例全部缓解。结论:鼻咽癌放化疗后并发突发性聋发病原因与放疗关系密切,听力损失较严重,治疗效果差。

Objective：To investigate the clinical features and therapeutic effects of sudden deafness after radiotherapy combined with chemotherapy in nasopharyngeal carcinoma patients.Method：Clinical data of 42 nasopharyngeal carcinoma patients suffered from sudden deafness after radiotherapy combined with chemotherapy were analyzed retrospectively.Among the 42 patients,2showed moderate deafness,4presented excessive deafness,30 suffered from severe deafness,and 6exhibited profound deafness.The audiogram pattern of 33 patients met with the type of high tone frequencies hearing loss,and that of the rest 9cases showed hearing loss at all frequencies.All patients received medical therapy combined with hyperbaric oxygen therapy.Result：Of all the cases with hearing loss,2were cured,2showed excellent recovery,9came out partial recovery,and 29 showed no response to the treatment.The total effective rate was 30.95%.For the accompanied symptoms,none of the 30 cases of tinnitus were relieved,3out of 10 cases of aural fullness were cured,and the 5cases of dizziness or vertigo were all improved.Conclusion：The sudden deafness after radiotherapy combined with chemotherapy in patients with nasopharyngeal carcinoma is closely related to radiotherapy.The hearing loss is serious,and the therapeutic effects are not satisfactory.