急性发作期梅尼埃病患者临床症状主成分分析

The principal component analysis of clinical symptoms in patients with Meniere′s disease during acute phase

目的：采用主成分分析的方法探讨急性发作期梅尼埃病患者疾病严重程度的综合评价指标。方法：对急性发作后24h内就诊的95例单侧梅尼埃病患者的临床症状进行主观评价和量化,听力损失（X1）和耳闷塞感（X4）的程度采用VAS评分,眩晕（X2）和耳鸣（X3）对患者的影响分别采用DHI和THI评分。对量化后的数据采用主成分分析PCA（principal component analysis）,构建疾病主观症状综合评价函数。结果：1梅尼埃病患者听力损失VAS评分（X1）为0-91分,平均值为46.23±18.80;眩晕DHI评分（X2）为8-98分,平均值为49.66±15.67;耳鸣THI评分（X3）为10-100分,平均值为47.53±17.44;耳闷塞感VAS评分（X4）为0-82分,平均值为21.55±27.54;2主成分Z1、Z2和Z3,其特征值分别为1.876、0.984、0.703,方差贡献率分别是46.898%、24.592%、17.574%;3构建的疾病综合评价函数=0.213ZX1＋0.398ZX2＋0.370ZX3＋0.455ZX4。结论：梅尼埃病的临床特征主观评价运用主成分分析法构建的综合评价模型可以较全面地综合四个主观症状所包含的信息,精简数据,整体反映疾病的严重程度。

Objective：To explore the severity index of Meniere′s disease during acute phase by a statistical method of principal component analysis（PCA）.Method：Ninety-five patients with Meniere′s disease in the acute phase who saw the doctor with 24 hours after onset were included in this study and their clinical data were analyzed retrospectively.The subjective symptoms of hearing loss（X1）and ear stuffy plug（X4）were evaluated by VAS scoring system,and the impact of vertigo（X2）and tinnitus（X3）on the patients were evaluated by DHI and THI score.The principal component analysis（PCA）method was used to analyze the quantified data and construct a synthetic evaluate function of subjective symptoms.Result：1The quantitative results of subjective symptoms in patients with Meniere′s disease were as follow：VAS score（X1）of hearing loss was 0-91 points,with an average of 46.23±18.80,DHI score（X2）of vertigo was 8-98 points,with an average of 49.66±15.67,THI score（X3）of tinnitus was 10-100 points,with an average of 47.53±17.44,and ear VAS score（X4）of stuffy plug feeling was 0-82 points,with an average of 21.55±27.54.2The eigenvalue of principal components Z1,Z2 and Z3were 1.876,0.984 and 0.703 respectively,and the variance contribution were 46.898%,24.592% and17.574% respectively.3The constructed synthetic evaluate function of the disease was as follow：The Meniere′s disease severity index=0.213ZX1＋0.398ZX2＋0.370ZX3＋0.455ZX4.Conclusion：The method of PCA for the subjective evaluation of symptoms in Meniere′s disease can be constructed as a model of comprehensive evaluation system,which may provide relatively comprehensive information of clinical original variables included in the four main symptoms,reflecting the severity of the disease.