摘要
钙库操纵性钙离子内流(store-operated calcium entry,SOCE)是介导胞外Ca2+进入细胞内的重要通道之一.其核心蛋白是位于内质网上的基质相互作用分子1(stromal interaction molecule 1,STIM1)及位于细胞膜上的钙释放激活钙通道蛋白1(calcium release-activated calcium channel protein 1,CRCM1/Orai1).随着研究的不断深入,SOCE通道在肿瘤中的作用机制逐渐阐明并加以完善,同样在消化系肿瘤中SOCE通道也发挥了重要作用.本文重点对SOCE通道基本信息、及其在消化系肿瘤中研究概况进行综述,并初步分析其作用机制.
Store-operated calcium entry（SOCE） is one of the important channels mediating extracellular Ca^（2＋） entry.Stromal interaction molecule 1（STIM1） protein in the membrane of endoplasmic reticulum and calcium releaseactivated calcium channel protein 1（CRCM1/Orail） protein in the plasma membrane are two key components of SOCE.Current research has gradually elucidated the mechanism of action of SOCE in tumors,and it has been demonstrated that SOCE plays an important role in digestive system tumors.This paper gives an overview of SOCE and reviews the current progress in understanding the role of SOCE in digestive system tumors.
出处
《世界华人消化杂志》
CAS
2015年第10期1609-1614,共6页
World Chinese Journal of Digestology
基金
国家自然科学基金资助项目
No.81472264~~
