摘要
RNA依赖的RNA聚合酶(RNA dependent RNA polymerase,RdRP)是一类以单链RNA为模板合成互补RNA链的聚合酶。根据其来源可分为病毒RdRP和细胞RdRP,病毒RdRP对病毒基因组复制及病毒引起的宿主免疫反应有重要作用,宿主细胞RdRP主要参与RNA干扰(RNA interference,RNAi)现象。越来越多研究证明RdRP的功能与非编码RNA(non-coding RNA,ncRNA)密不可分,本文对病毒RdRP、细胞RdRP与ncRNA调控之间的关系作了较详细的阐述,同时对丙型肝炎病毒(hepatitis C virus,HCV)诱发的肝癌机制提出新的观点。
RNA dependent RNA polymerases（RdRPs）can synthesize complementary RNA strands by RNA templates.They can be classified as viral RdRPs and cellular RdRPs by their origins.Viral RdRPs are essential to viral genome replication and play an important role in host immune response.Additionally,cellular RdRPs are mainly involved in RNA interference（RNAi）.The current research shows an inextricable connection between RdRP functions and non-coding RNA（ncRNA）regulation.Here we summarizes the functions of viral RdRPs and cellular RdRPs in ncRNA regulation,and proposes new ideas regarding hepatitis C virus（HCV）induced hepatoma-genesis.
出处
《复旦学报（医学版）》
CAS
CSCD
北大核心
2015年第2期256-261,共6页
Fudan University Journal of Medical Sciences
基金
国家自然科学基金面上项目(31271355)~~
