甘肃农村地区癫痫患者生活质量及其影响因素调查

Quality of life and the related factors in patients with epilepsy in rural area of Gansu province

目的研究甘肃农村地区成年癫痫患者的生活质量及其影响因素。方法采用癫痫患者生活质量量表-31(quality of life in epilepsy inventory,QOLIE-31)对甘肃省农村地区154例癫痫患者及149名正常对照进行生活质量评估,分析社会人口学因素(性别、年龄、婚姻状况、职业、教育程度等)和临床因素(癫痫起病年龄、病程、发作类型、发作频率、服用药物种数等)对患者生活质量的影响。结果患者生活质量得分低于对照组[(47.63±7.74)vs.(52.28±5.75)],差异有统计学意义(P<0.05)。不同性别、婚姻状况、职业、受教育程度、发作类型的患者生活质量得分无统计学差异(P>0.05),不同人均年收入、服用药物种数的患者生活质量得分有统计学差异(P<0.05)。经多因素线性回归分析,患者家庭人均年收入(β=3.115,P=0.002)、服用药物种数(β=3.261,P=0.027)是影响其生活质量的因素。结论成年癫痫患者生活质量较低,家庭经济状况、服用药物种类对患者生活质量影响较显著,合理选择药物是控制癫痫发作、减轻家庭经济负担、提高癫痫患者生活质量的有效措施。

ObjectiveTo explore the quality of life and the related factors in adult epilepsy patients in rural areas ofGansu province.MethodsThe Quality of Life in the Epilepsy-31 Inventory Chinese version（QOLIE-31） were used toevaluate the quality of life in 154 epilepsy patients and 149 healthy controls. The relationship of demographic variables（gender, age, marital status, profession and education, etc.） and clinical variables（age of onset, duration, type of seizures,seizure frequency and medication, etc.） with the quality of life were analyzed in patients.ResultsCompared with the con-trol group, the QOLIE-31 score was significantly lower in epileptic group [（47.63±7.74） vs.（52.28±5.75）, P 〈0.05]. Therewas no significant difference in the patients’ QOLIE-31 score between difference ages, genders, marital status, occupa-tions, and educations（P 〉0.05）. The differences of patients’ QOLIE-31 score were significantly different between differ-ent incomes, medication types of epilepsy（P 〈0.05）. The patient’s family income（β=3.115, P=0.002） and the type of medi-cation（β=3.261, P=0.027） were factors affecting their quality of life.ConclusionThe quality of life in adult patients withepilepsy is lower. Economic status of family and the number of drug type significantly affects the quality of life in patients.Reasonable drug choice to treat seizure and reduce the economic burden of the family are effective measures to improvethe quality of life of patients with epilepsy.