摘要
目的评估早期肠内营养(EEN)对重症颅脑损伤患者炎症反应的影响。方法选取2012年7月到2014年7月我院外科ICU和神经外科收治的重症颅脑损伤患者140例,将患者随机分为研究组和对照组,对照组给予肠外营养(PN),研究组给予EEN,记录两组患者治疗1、3、5、7、14 d血清C反应蛋白(CRP)水平和格拉斯哥昏迷评分(GCS);记录两组患者治疗7 d及14 d血清总蛋白、血清白蛋白、外周淋巴细胞计数。结果治疗后两组CRP均下降,治疗1 d两组CRP比较差异无统计学意义(P>0.05),研究组3、5、7、14 d CRP低于对照组,两组比较差异有统计学意义(P<0.05);两组1、3、5、7 d GCS比较差异无统计学意义(P>0.05),第14天研究组GCS评分高于对照组,两组比较差异有统计学意义(P<0.05)。两组治疗后第7天及第14天血清总蛋白、血清白蛋白、外周淋巴细胞计数均有上升,上述指标研究组高于对照组,两组比较差异有统计学差异(P<0.05)。结论 EEN与PN相比减轻了重症颅脑损伤患者的炎症反应,有助于患者从昏迷中恢复,改善了患者机体的内环境。
Objective To evaluate the influence of early enteral nutrition （EEN） on inflammation in pa- tients with severe traumatic brain injury. Methods One hundred and forty cases with severe traumatic brain injury were included in the study from July 2012 to July 2014.The patients were randomly divided into the study group （n = 70） and the control group （n = 70）, and were given parenteral nutrition（PN） and EEN re- spectively. The serum C-reactive protein （CRP） level and Glasgow Coma Score （GCS） of ld, 3d, 5d, 7d and 14d in two groups were collected. Total serum protein, serum albumin and serum lymphocyte count of 7d and 14d in two groups were collected. Results The serum CRP level in two groups decreased, and there were no differences in the CRP of ld（P 〉 0.05）, and the CRP of 3d, 5d, 7d and 14d in the study group was significantly lower than that in the control group （P 〈 0.05）. There were no differences in the GCS of I d, 3 d, 5 d and 7 d between two groups（P 〉 0.05）, and the GCS of 14 d in the study group was significantly higher than that in the control group （P 〈 0.05）. Total serum protein, serum albumin and serum lymphocyte count of 7 d and 14 d in two groups increased, and the above indexes in the study group were higher than that in the control group（P 〈 0.05）. Conclusion EEN reduces inflammation, helps patients to recover from the coma, and improves the in- ternal environment in severe traumatic brain injury compared with PN.
出处
《现代消化及介入诊疗》
2015年第1期19-21,共3页
Modern Interventional Diagnosis and Treatment in Gastroenterology
