维生素D联合二甲双胍对多囊卵巢综合征患者排卵及子宫内膜容受性的影响研究

Effect of vitamin D in combination with metformin in treatment of patients with PCOS ovulation and the receptivity of endometrium

目的探究维生素D联合二甲双胍对多囊卵巢综合征患者排卵及子宫内膜容受性的影响。方法选取某院妇科收治的多囊卵巢综合征108例,采用双盲随机分为两组。对照组52例,患者口服二甲双胍500 mg,3次/d,4周为一个疗程;观察组56例,在口服二甲双胍的基础上用维生素D,口服1200 IU/d,4周为一个疗程。一个疗程结束后,对两组患者排卵、子宫内膜容受性等情况进行比较分析。结果 1治疗后,观察组排卵周期数、排卵例数及总排卵率(25、18、32.14%)显著高于对照组(13、6、11.53%),差异有统计学意义(P<0.05);2治疗后,两组患者子宫内膜厚度均有所减小,且观察组(6.29±2.71、82.19%)显著优于对照组(7.69±2.53、89.32%),差异有统计学意义(P<0.05),两组患者子宫内膜多层率均有所下降,且观察组显著低于对照组,差异有统计学意义(P<0.05);3治疗后,两组患者子宫内膜血流量有所下降,且观察组(60.23%)显著低于对照组(88.91%),差异有统计学意义(P<0.05);4治疗后,观察组患者Salle评分13.27分显著低于对照组17.52分,差异有统计学意义(P<0.05)。结论维生素D联合二甲双胍可有效提高患者排卵率、减少子宫内膜增厚、减轻子宫多层率、改善子宫血管血流量,是治疗多囊卵巢综合征患者的有效药物,值得临床推广。

Objective To explore the effect of vitamin D in combination with metformin ovulation in treatment of patients with polycystic ovary syndrome（PCOS） and the receptivity of endometrium.Methods 108 cases of patients with polycystic ovary syndrome treated in department of gynaecology,were randomly divided into two groups by double blinding.52 cases were treated with routine western medicine,with oral metformin 500 mg / d,taking three times,four weeks for a period of treatment.Experimental group with 56 cases,on the basis of conventional western medicine treatment with vitamin D,oral 1200 IU / d,four weeks for a period of treatment.After a period of treatment,two groups of patients with ovulation,carry on comparative analysis to the receptivity of endometrium.Results 1After treatment,patients in the experimental group with ovulation cycle number,ovulation occurring and total ovulation rate（25,18,32.14%） was significantly higher than that of control group（13,6,11.53%）,the difference was statistically significant（P〈0.05）.2Two groups of patients with endometrial thickness is reduced after treatment,and the experimental group（6.29 ± 2.71,82.19%） was significantly better than the control group（7.69 ± 2.53,89.32%）,the difference was statistically significant（P〈0.05）.Two groups of patients with endometrial multilayer rate were decreased.The experimental group was significantly lower than the control group,the difference was statistically significant（P〈0.05）.3After treatment,two groups of patients with endometrial blood flow rate were decreased,and the experimental group（60.23%） was significantly lower than the control group（88.91%）,the difference was statistically significant（P〈0.05）.4Two groups of patients after total effective salle grading comparison：after treatment,the experimental group（13.27） in patients with salle score was significantly lower than the control group（17.52）,the difference was statistically significant（P〈0.05）.Conclusion Vitamin D in combination with metformin cocoa effectively increase ovulation rate,reduce the patients with endometrial thickening,reduce multilayer rate,improve and vascular blood flow,the uterus is an effective drug for treatment of patients with polycystic ovary syndrome,and is worth clinical popularizing widely.