17例白色萎缩临床病理分析并治疗探讨

Analysis and treatment of 17 cases of atrophic blanche

目的提高对白色萎缩早期诊断能力和发病机制的认识,探讨有效的治疗方法。方法对第二军医大学附属长海医院2005-2014年诊治的白色萎缩17例的临床资料进行回顾性分析,包括临床、病理及不同的治疗方法与效果。结果多见于青年女性,皮损好发于下肢;15例血管腔内有透明血栓形成(占88.2%);双嘧达莫及达那唑、利伐沙班治疗效果较好;早期误诊9例(占52.9%)。结论临床特点及早期的组织病理学检查为诊断本病的依据,医务人员应加强对早期白色萎缩的认识,利伐沙班可能有助于该病的治疗和减少复发。

Objective To analyse clinical and pathological presentation of 17 cases of atrophic blanche and to discuss the result of the treatment.Methods A retrospective analysis of the clinica1 data from 17 patients with this disorder in changhai hospital,data including clinical and pathological presentation and treatment.Results The disease was mostly seen in young women of the lower extremities.15 of 17 patients（88.2%） had thrombus formation in the lumen of blood vessels.The good choice of treatment is use of dipyridamole combined with rivaroxaban and danazol.9 cases of misdiagnosis of the disease,the rate of early misdiagnosis about52.9%.Conclusion The diagnosis of this disorder is mainly dependent on clinical features and histopathologic changes.Medical personnel should be alerted to the diagnosis of atrophic blanche.Rivaroxaban may be helpful to treat the disease and reduce its relapse.