饮酒与老年脑卒中患者伴发肺炎的Meta分析

The Metaanalysis for the association between alcohol consuming and stroke associated pneumonia

目的系统评价饮酒与老年脑卒中患者伴发肺炎关系。方法计算机检索Cochrane Library、Pub Med、Medline、EM-base、万方、CNKI、维普等数据库,收集饮酒与老年脑卒中患者伴发肺炎的随机对照试验(RCT),检索时限均从建库至2014年1月。两名研究者按照纳入排除标准独立筛选文献、提取资料和质量评价后,采用Rev Man 5.1软件进行Meta分析。结果纳入11个病例对照研究,Meta分析结果显示9个研究报告了全部研究对象中饮酒因素与卒中相关性肺炎(stroke associated pneumonia,SAP)的关联,合并后的饮酒因素是SAP发生的危险因素,存在统计学意义(OR=165.00)。有4个研究报告了女性饮酒因素与SAP的关联,合并后的饮酒因素(OR=125.04)。6个研究报告了男性饮酒因素与SAP的关联,合并后的饮酒因素(OR=85.22)。有8个研究报告了65岁以上老年人饮酒因素与SAP的关联,合并后的饮酒因素(OR=675.44)。从漏斗图分析可见,Meta分析计算所得合并效应量稍倾向于高估研究因素的危险性。结论本研究结果提示男性、女性、老年人群以及普通人群中均存在饮酒增加脑卒中合并肺炎的发病风险,值得临床预防工作者借鉴。

Objective To evaluate the association between alcohol consumption and stroke associated pneumonia.Methods We searched the Cochrane Library,Pub Med,Medline,EM-base,Wan Fang Data,CNKI,VIP and other databases,collect monoclonal antibody targeted therapy with chemotherapy with chemotherapy alone treatment of gastric cancer effects of randomized controlled trials（RCT）,the time limits are retrieved from building a database to January 2014.Two researchers independently screened according to inclusion and exclusion criteria literature,data extraction and quality assessment after using Rev Man 5.1 software Meta-analysis.Results11 case-control studies were included.Meta analysis showed that nine studies reported drinking in the study as a factor associated with SAP,the combined effect of alcohol drinking is still a risk factor SAP,with statistically significant[OR = 165.00].There are four studies focused on the female population,and study reported drinking was associated with SAP,OR = 125.04.Six studies reported the association between alcohol consumption and SAP in males,combined OR = 85.22.There are eight study reported in the population of older than 65 year old,drinking factor was associated with SAP,OR = 675.44.The funnel plots suggested that the combined effect inclined to overestimate the risk factors in this manuscript.The systematic review of clinical practice and research conclusions reference purposes only.Conclusion The results suggested that for male,female,the elderly population or the general population,alcohol drinking may increased the risk of stroke associated pneumonia phenomenon,which might be worthy for the clinical and preventive work.