期刊文献+
任意字段
题名或关键词
题名
关键词
文摘
作者
第一作者
机构
刊名
分类号
参考文献
作者简介
基金资助
栏目信息

粒-巨噬细胞集落刺激因子及其受体拮抗剂mavrilimumab在类风湿关节炎中研究进展 被引量：2

原文传递
导出
摘要 RA是一种系统性慢性自身免疫性疾病,以持续侵蚀性的炎症性多关节炎为主要临床表现,除关节外,也可累及肺、心脏、皮肤等其他脏器,如果没有得到合理的治疗,将导致关节毁损和瘫痪,生活质量下降和寿命缩短.粒-巨噬细胞集落刺激因子（granulocyte-macrophage colony stimulating factor,GM-CSF）是一种具有多效性的造血细胞生长因子,在粒细胞系与巨噬细胞系的发育与成熟的各阶段起到调控作用.近年研究表明GM-CSF在炎症反应与自身免疫疾病中有重要作用,GM-CSF参与RA发病,而其受体拮抗剂mavrilimumab能够拮抗GM-CSF信号传导,显著改善关节炎小鼠的症状.为此,本文将综述GM-CSF及其受体拮抗剂mavrilimumab在RA治疗中的研究进展.
作者 盛君 陆进明
机构地区 安徽省皖南医学院附属医院风湿免疫科
出处 《中华风湿病学杂志》 CAS CSCD 北大核心 2015年第4期285-288,共4页 Chinese Journal of Rheumatology
关键词 粒-巨噬细胞集落刺激因子 类风湿关节炎 受体拮抗剂 GM-CSF 慢性自身免疫性疾病 造血细胞生长因子 自身免疫疾病 巨噬细胞系
分类号 R593.22 [医药卫生—内科学]
  • 相关文献

参考文献30

  • 1Hansen G, Hercus TR, McClure BJ, et al. The structure of the GM-CSF receptor complex reveals a distinct mode of cytokine receptor activation[J]. Cell, 2008, 134(3): 496-507.
  • 2Fleetwood A J, Lawrence T, Hamilton JA, et al. Granulocyte- macrophage colony-stimulating factor (CSF) and macrophage CSF-dependent macrophage phenotypes display differences in cytokine profiles and transcription factor activities: implications for CSF blockade in inflammation[J]. J Immunol, 2007, 178 (8) : 5245-5252.
  • 3Campbell 1K, van Nieuwenhuijze A, Segura E, et al. Differen- tiation of inflammatory dendritic cells is mediated by NF-KB1- dependent GM-CSF production in CD4T cells[J]. J Immunnl, 2011, 186(9): 5468-5477.
  • 4Codarri L, Gyillvrszi G, Tosevski V, et al. ROR'tt drives production of the cytokine GM-CSF in helper T cells, which is essential for the cffector phase of autoimmune neuroinflammation [J]. Nat Immunol, 2011, 12(6): 560-567.
  • 5E1-Behi M, Ciric B, Dai H, et al. The encephalitogenieity of TH17 cells is dependent on IL-l-and IL-23-induced production of the cytokine GM-CSF[J]. Nat Immunol, 2011, 12(6):568-575.
  • 6Poppensieker K, Otte DM, Schuermann B, et al. CC ehemokine receptor 4 is required for experimental autoimmune encephalo- myelitis by regulating GM-CSF and IL-23 production in dendrltie cells[J]. Proc Natl Acad Sci USA, 2012, 109(10):3897-3902.
  • 7Sonderegger I, Iezzi G, Maier R, et al. GM-CSF mediates autoimmunity by enhancing IL-6 dependent Th17 cell development and survival[J]. J Exp Med, 2008, 205(10): 2281- 2294.
  • 8Suzuki T, Sakagami T, Rubin BK, et 81. Familial pulmonary alveolar proteinosis caused by mutations in CSF2RA[J]. J Exp Med, 2008, 205 (12) : 2703-2710.
  • 9Stanley E, Lieschke GJ, Grail D,et al. Granulocyte/macrophage colony-stimulating factor-deficient mice show no major pertur- bation of hematopoiesis but develop a characteristic pulmonary pathology[J]. Proe Natl Acad Sci USA, 1994, 91(12): 5592- 5596.
  • 10Uchida K, Nakata K, Suzuki T, et al. Granulocyte/macro- phagecolony-stimulating factor autoantibodies and myeloid cell immune functions in healthy subjects [J]. Blood, 2009, 113(11): 2547-2556.

二级参考文献35

  • 1Smolen JS, Steiner G. Rheumatoid arthritis is more than cytokines: autoimmunity and rheumatoid arthritis [ J]. Arthritis Rheum,2001, 44(10) :2218-2220.
  • 2Steiner G, Smolen J. Autoantibodies in rheuma- toid arthritis and their clinical significance [J]. Arthritis Res ,2002,4 ( Suppl 2 ) : S1 -S5.
  • 3Firestein GS, Zvaifler NJ. How important are T cells in chronic rheumatoid synovitis ?: II T cell- independent mechanisms from beginning to end [ J ]. Arthritis Rheum, 2002,46 (2) :298-308.
  • 4Feldmann M. Development of anti-TNF therapy for rheumatoid arthritis [ J ]. Nat Rev Immunol, 2002,2 ( 5 ) : 364-371.
  • 5Kunisada T, Miyazaki M, Mihara K, et al. A new human chondrosarcoma cell line (OUMS-27) that maintains chondrocytic differentiation [ J ]. Int J Cancer, 1998,77(6) :854-859.
  • 6Altman R, Asch E, Bloch D, et al. Development of criteria for the classification and reporting of osteo- arthritis. Classification of osteoarthritis of the knee. Diagnostic and Therapeutic Criteria Committee of the American Rheumatism Association [ J ]. ArthritisRheum, 1986, 29 (8) : 1039-1049.
  • 7Arnett FC, Edworthy SM, Bloeh DA, et al. The American Rheumatism Association 1987 revised cri- teria for the classification of rheumatoid arthritis[ J]. Arthritis Rheum, 1988,31 (3) :315-324.
  • 8Shimada S, Nakamura M, Tanaka Y. Crosslinking of the CD69 molecule enhances S100A9 production in activated neutrophils [ J ]. Microbiol Immunol, 2007, 51(1) :87-98.
  • 9Tschesche H, Zolzer V, Triebel S, et al. The human neutrophil lipocalin supports the allosteric activation of matrix metalloproteinases [ J ]. Eur J Biochem, 2001, 268(7) :1918-1928.
  • 10Yan L, Borregaard N, Kjeldsen L, et al. The high molecular weight urinary matrix metalloproteinase (MMP) activity is a complex of gelatinase B/MMP-9 and neutrophil gelatinase-associated lipocalin (NGAL). Modulation of MMP-9 activity by NGAL [J]. J Biol Chem, 2001, 276(40):37258-37265.

共引文献49

同被引文献9

引证文献2

二级引证文献14

中华风湿病学杂志
2015年 第4期

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部