卵巢无性细胞瘤临床病理分析

Clinical pathological analysis of ovarian dysgerminoma

目的探讨卵巢无性细胞瘤的临床病理特征、诊断与鉴别诊断要点。方法对18例卵巢无性细胞瘤进行组织形态学、免疫组化染色观察,结合文献对其临床表现、病理形态特点及鉴别诊断进行分析。结果临床主要症状为下腹包块、腹痛腹胀,肿瘤大体为卵圆形或结节状,平均直径10 cm,包膜完整,粉红至棕褐色,切面实性分叶状,可见出血或坏死。镜下为单一的大细胞排列成巢片、团块状,由含有不同数目淋巴细胞的纤细的结缔组织将其分隔。免疫组化:PLAP和CD117均为膜阳性。结论卵巢无性细胞瘤发病率低,常发生于30岁以下,单纯性无性细胞瘤预后较好,而混合型无性细胞瘤预后差。掌握该肿瘤的特征性组织形态、免疫组化,对鉴别其他卵巢肿瘤有重要帮助。

Objective To investigate the clinical pathological characteristics of ovarian dysgerminoma,key points of diagnosis and differential diagnosis. Methods Eighteen cases of ovarian dysgerminoma were given histomorphology,immunohistochemical staining observation,combined with the literature on its clinical manifestation,pathological morphological features and differential diagnosis were analyzed. Results Clinical main symptoms were abdominal mass,abdominal pain,abdominal distension,broadly ovoid or nodular tumor,an average of about 10 cm in diameter,membrane integrity,pink and tan,with a solid plane,lobulated visible hemorrhage or necrosis. Microscopically into a single large cells arranged in nests,crumb,by thin connective tissue containing different number of lymphocytes to separate it. Immunohistochemical： PLAP and CD117 positive for film. Postoperative chemotherapy in all 18 cases. Conclusion Low incidence of ovarian dysgerminoma,often occurred in 30 years old the following,simple dysgerminoma prognosis is good,and mixed dysgerminoma has poor prognosis. Master the characteristic of tumor tissue morphology and immunohistochemistry,help to identify other ovarian tumors.