脑梗死患者血清Hcy、UA与头颈部血管动脉粥样硬化及狭窄的相关性

Correlation of serum Hcy and UA with the atherosclerosis and stenosis of head and neck vascular in patients with cerebral infarction

目的探讨脑梗死患者血清同型半胱氨酸(Hcy)、血尿酸(UA)与头颈部血管动脉粥样硬化及狭窄的相关性。方法采用回顾性方法分析淅川县人民医院2012年12月至2013年12月收治的86例脑梗死患者的临床资料。采用多层螺旋CT连续扫描,分为头颈部血管有动脉粥样硬化组与无动脉粥样硬化组,两组各43例。再将头颈部血管有动脉粥样硬化组根据血管狭窄分为轻、中、重度,比较各组的血清Hcy、UA水平。结果有动脉粥样硬化者的血清Hcy、UA水平均明显高于无动脉粥样硬化者,其差异有统计学意义(P<0.05);动脉粥样硬化重度狭窄患者的血清Hcy、UA水平明显高于轻度、中度患者,其差异有统计学意义(P<0.05);血清Hcy、UA水平均升高时,重度狭窄者明显高于血清Hcy、UA水平单一升高,其差异有统计学意义(P<0.05)。结论脑梗死患者血清高Hcy及UA水平均与头颈部血管动脉粥样硬化、狭窄相关,若两者同时升高,极易使患者重度狭窄。

Objective To investigate the correlation of serum homocysteine（ Hcy）,blood uric acid（ UA） with aherosclerosis and stenosis of head and neck vascular in patients with cerebral infarction. Methods The clinical data of 86 patients with cerebral infarction admitted in our hospital from December 2012 to December 2013 were retrospectively analyzed. The patients were divided into head and neck vascular atherosclerosis group and non atherosclerosis group by multislice spiral CT scanning,with 43 cases in each group. Then the head and neck vascular atherosclerosis group were divided into light,morderate and severe group according to the stenosis degree,and the serum Hcy,UA levels in each group were compared. Results The serum levels of Hcy,UA in patients with atherosclerosis were significantly higher than those in patients with without atherosclerosis,and the differences were significant（ P〈0. 05）; the serum Hcy,UA levels in patients with severe stenosis of atherosclerosis were significantly higher than those in patients with mild and moderate stenosis,the differences were significant（ P〈0. 05）; the serum Hcy,UA levels rised,patients with severe stenosis were obviously more than that of serum Hcy,UA level single increased,the difference was significant（ P〈0. 05）. Conclusion High serum Hcy and UA levels were correlated with atherosclerosis stenosis of head and neck vascular in patients with cerebral infarction,if the two are increasing at the same time,patients are prone to have severe stenosis.