奥美拉唑、阿莫西林和克拉霉索联合治疗胃溃疡的疗效

Effect of combination therapy of omeprazole,amoxicillin and clarithromycin on gastric ulcer

目的观察奥美拉唑、阿莫西林和克拉霉索三者联合用药治疗胃溃疡的疗效。方法选择2012年7月至2013年11月于永城市中心医院治疗的胃溃疡患者100例作为研究对象,以随机数表法分为观察组和对照组(各50例)。观察组行奥美拉唑、阿莫西林和克拉霉索三种药物联合治疗;对照组使用奥美拉唑、阿莫西林和甲硝唑三者药物联合诊治,对比观察两组的疗效。结果比较两组患者不适现象发生情况,观察组发生率较对照组明显更低。两组患者进行治疗后,观察组疗效为优者占78.00%(39/50)、优良率达到98.00%(49/50),均显著高于对照组的56.00%(28/50)、80.00%(40/50)。差异均有统计学意义(P<0.05)。结论奥美拉唑、阿莫西林和克拉霉索联合使用对胃溃疡进行治疗,能够有效缓解患者临床症状,减轻家庭经济负担,效果较好,且安全性较高,值得临床推荐。

Objective To observe the effect of omeprazole,amoxicillin combined with clarithromycin on gastric ulcer.Methods One hundred cases of gastric ulcer admitted in central hospital of Yongcheng from July 2012 to November 2013 were selected as research subjects,and randomly divided into observation group and control group（ fifty cases in each group）. The observation group was treated with combination treatment of omeprazole,amoxicillin and clarithromycin,and the control group was treated with omeprazole,amoxicillin and metronidazole. Results The occurrence of discomfort of the two groups were compared,and the incidence in the observation group was significantly lower than that in the control group. The excellent cases in observation group was 39,accounting for 78. 00%,the rate of excellent and good was 98. 00%（ 49 /50）. Both of them were significantly higher than that of control group,which were 56. 00%（ 28 /50） and 80. 00（ 40 /50）. The differences were statistically significant（ P〈0. 05）. Conclusion The combination of omeprazole,amoxicillin and clarithromycin can effectively relieve symptoms and reduce the economic burden of the family,so it is worthy of recommendation clinically.