生长抑素联合铝碳酸镁对老年NSAIDs出血糜烂性胃炎GAS和PGE2的影响及疗效分析

The effect of somatostatin combined with hydrotalcite on GAS and PGE2 expression in senile NSAIDs-related hemorrhage erosive gastritis

[目的]探讨生长抑素联合铝碳酸镁片对NSAIDs致老年急性出血糜烂性胃炎GAS和PGE2的影响以及疗效分析。[方法]将80例NSAIDs致老年急性出血糜烂性胃炎随机分为研究组和对照组,每组各40例。对照组患者给予铝碳酸镁片治疗,研究组患者在此基础上加用生长抑素治疗。ELISA法测定GAS和PEG2水平,比较2组患者的临床症状消失时间和治疗有效率。[结果]研究组患者黑便消失时间、大便潜血消失时间和住院时间分别为(3.9±0.6)d、(6.3±1.0)d和(7.9±1.2)d显著短于对照组的(5.4±0.9)d、(8.4±1.2)d和(10.4±1.5)d(P<0.05)。治疗前2组GAS和PGE2水平差异无统计学意义,治疗后2组GAS含量均显著降低、PGE2含量均显著升高(P<0.05和P<0.01),治疗后研究组对与GAS和PGE2的改善作用显著优于对照组(P<0.05)。研究组患者治疗有效率为97.5%高于对照组的85.0%(P<0.05)。2组间不良反应发生率差异无统计学意义。[结论]生长抑素联合铝碳酸镁片对NSAIDs致老年急性出血糜烂性胃炎的效果良好,具有临床应用价值。

[Objective]To detect the effect of somatostatin combined with hydrotalcite on GAS and PGE2 expression in senile NSAIDs-related hemorrhage erosive gastritis.[Methods]A total of 80 senile NSAIDs-related hemorrhage erosive gastritis patients were devided into study group（n=40）and control group（n=40）.Patients in control group were treated with hydrotalcite tablets,and patients in study group were treated with hydrotalcite tablets and somatostatin.The protein expression of GAS and PGE2 was detected with ELISA assay.Clinical symptoms disappeared time and treatment efficiency were compared between the two groups.[Results]Melena disappeared time,fecal occult blood disappearance time and hospitalization time in study group were（3.9±0.6）d,（6.3±1.0）d and（7.9±1.2）d,which were significantly shorter than that of（5.4±0.9）d,（8.4±1.2）d and（10.4±1.5）d in control group（P〈0.05）.Before treatment,there was no significant difference of GAS and PGE2 levels between the two groups.After treatment,GAS and PGE2 was significantly increased in the two groups（P〈0.05 and P〈0.01）.However,the improvement was better in study group than in control group（P〈0.05）.The effective rate in study group was 97.5%,which was higher than that of 85.0%in control group（P〈0.05）.The incidence of adverse reactions had no statistical difference between the two groups（P〉0.05）.[Conclusion]Somatostatin combined with Hydrotalcite can improve the effective rate in treating NSAIDs induced senile acute hemorrhagic erosive gastritis,which has clinical value