易坦净联合孟鲁司特对儿童咳嗽变异性哮喘的临床疗效和肺功能的影响

The Clinical Effect and Pulmonary Function of Yi Tanjing Combined with Montelukast for Children with Cough Variant Asthma

目的探讨易坦净联合孟鲁司特对儿童咳嗽变异性哮喘的临床治疗效果,并观察肺功能的改善,为临床合理治疗提供依据。方法选择本院2011年12月至2013年12月收治的咳嗽变异性哮喘患儿90例,根据治疗方法分为对照组和观察组,两组各45例,对照组应用孟鲁司特治疗;观察组在对照组基础上给予易坦净联合治疗。评估患者的肺功能:一秒用力呼气量(FEV1)、FEV1/用力肺活量(FVC)和最大呼气峰流速(PEF)占预计值百分比等肺功能指标。评估临床治疗效果、评估患儿咳嗽明显缓解时间及咳嗽消失时间。结果对照组和观察组治疗后FEV1、FEV1/FV(%)C和FEV占预计值(%)与治疗前比较,差异具有统计学意义(P<0.05);观察组患者治疗后FEV1、FEV1/FV(%)C和FEV占预计值(%)分别为2.94±0.61L、71.88±2.56%和94.63±3.86%,均高于对照组治疗后2.80±0.57L、67.79±3.10%和89.93±5.20%,差异有统计学意义(P<0.05)。观察组总有效率为86.67%(39/45),高于对照组66.67%(30/45),差异有统计学意义(P<0.05);观察组患儿咳嗽缓解和咳嗽消失时间结果比较分别为5.04±0.29d和6.82±0.57 d,均少于对照组,差异有统计学意义(P<0.05)。结论易坦净联合孟鲁司特对儿童咳嗽变异性哮喘的临床治疗效果较好,能够明显缩短症状或体征改善和消失时间,并改善患儿肺功能。

OBJECTIVE To explore the clinical effect of Yi Tanjing combined with montelukast for children with cough variant asthma,and to observe the improvement of lung function,to provide a basis for clinical rational treatment.METHODS 90 children with cough variant asthma were selected in the hospital from December in 2011 to December in 2013,according to treatment methods they were divided into the observation group and the control group,45 cases in each group.The control group using montelukast treatment,the observation group given Yi Tanjing combination therapy based on the control group.The pulmonary function of patients were evaluated： the forced expiratory volume in 1 second（FEV1）,FEV1/forced vital capacity（FVC） and peak expiratory flow（PEF） for the percentage of pulmonary function.Clinical treatment,cough relief time and the cough disappearance time were evaluated.RESULTS The observation group and the control group after treatment,FEV1,FEV1/FVC（%） and FEV（%）compared with that before treatment,the difference was statistically significant（P〈0.05）.After treatment,FEV1,FEV1/FVC and FEV（%） of the observation group were 2.94 ± 0.61 L,71.88 ± 2.56% and 94.63 ± 3.86%,higher than the control group 2.80 ± 0.57 L,67.79 ± 3.10% and 89.93 ± 5.20%,the difference was statistically significant（P〈0.05）.The total effective rate of the observation group was 86.67%（39/45）,more than that of control group 66.67%（30/45）,the difference was statistically significant（P〈0.05）.The cough and cough relieving disappear time results of the observation group were 5.04 ± 0.29 d and 6.82 ± 0.57 d,significantly less than the control group,the difference was statistically significant（P〈0.05）.CONCLUSION There was better effect on Yi Tanjing combined with montelukast for the treatment of cough variant asthma in children,which could significantly shorten the symptoms or signs of improvement and the disappearance time,and improve lung function.