血清CEA和CA125水平对间质性肺病癌变的早期诊断学研究

Diagnostic value of CEA and CA125 in patient with interstitial lung disease complicated with lung cancer

目的比较ILD患者和ILD合并肺癌患者血清CEA和CA125的水平,探讨其在ILD合并肺癌早期诊断中的临床应用价值。方法设置ILD合并肺癌组（n=42）、ILD组（n=70）和对照组（n=60）,测定并比较两组患者血清CEA和CA125的水平,通过受试者工作曲线评价CEA和CA125对ILD合并肺癌的诊断价值。结果 ILD合并肺癌组血清CEA、CA125水平均高于ILD组和对照组（P〈0.05）;ILD组血清CEA、CA125水平均高于对照组（P〈0.05）;血清CEA和CA125在诊断ILD合并肺癌的曲线下面积（area under curve,AUC）分别为0.722（95%CI：0.633-0.769,P〈0.05）,0.751（95%CI：0.658-0.791,P〈0.05）。当血清CEA为6.2 ng/m L时,其诊断的敏感度为72.3%,特异度为69.2%;当血清CA125为60.4U/m L时,其诊断的敏感度为75.3%,特异度为79.7%。结论 ILD合并肺癌患者血清CEA和CA125较ILD患者要高,血清CEA和CA125对ILD合并肺癌的早期诊断具有参考价值。

Objective To investigate the diagnostic value of CEA and CA125 in patient with interstitial lung disease（ ILD） complicated with lung cancer. Methods The serum levels of CEA and CA125 were detected in 42 patients with ILD complicated with lung cancer,70 patients with ILD only and 60 patients with common pneumonia.Receiver operating characteristic（ ROC） curve was used to estimate the CEA and CA125 diagnostic value of ILD complicated with lung cancer. Results The serum levels of CEA and CA125 were higher in ILD complicated with lung cancer patients than in those with ILD（ P〈0.05） and the control group（ P〈0.05）. ROC curve analysis showed a cut-off point of 6. 2 ng / m L for CEA and 60. 4 U / m L for CA125 with sensitivities of 72. 3% and75. 3%,specificities of 69. 2% and 79. 7%,and the areas under the curve（ AUC） were 0. 722（ 95% CI： 0. 633 - 0. 769,P〈0.05） and 0. 751（ 95% CI： 0. 658 - 0. 791,P〈0.05） respectively. Conclusion The levels of serum CEA and CA125 increases in ILD complicated with lung cancer patients,which can be used as tumor markers for the early diagnosis of lung cancer.