氨茶碱对CVA患者Th1/Th2及FeNO的影响

Effect of aminophylline on Th1/Th2 and FeNO in patients with CAV

目的探讨氨茶碱对咳嗽变异性哮喘(CVA)患者Thl/Th2平衡的调节及气道炎症的影响。方法将78例咳嗽变异性哮喘患者随机分为对照组和治疗组各39例。对照组予以布地耐德雾化吸入治疗;治疗组在对照组基础上加用氨茶碱缓释片0.1 g每日2次口服。两组治疗前均行IFN-γ、IL-4检测,计算IFN-γ/IL-4比值,呼出气一氧化氮(Fe NO)检测评估气道炎症,2周为一疗程。结果治疗前两组IFN-γ和IL-4水平、IFN-γ/IL-4比值及Fe NO基本一致(P>0.05);治疗后IFN-γ/IL-4比值,治疗组明显高于对照组(P<0.05),治疗组Fe NO下降高于对照组(P<0.05)。结论氨茶碱对CVA患者的Thl/Th2平衡有一定的调节作用,可改善CVA患者的气道炎症,有一定的临床推广价值。

Objective To investigate the effect of aminophylline on Thl/Th2 balanced regulation and airway inflammation in patients with cough variant asthma（ CVA）. Methods 78 cases of cough variant asthma patients were randomly divided into the control group and the treatment group,with 39 patients in each group. The control group received budesonide inhalation therapy,and the treatment group was additionally given 0. 1g aminophylline tablets,twice daily. Before the treatment,the level of IFN-γ,IL-4 and Fe NO was detected,and the ratio of IFN-γ to IL-4 was calculated. Two weeks were a course of treatment. Results Before the treatment,there was no significant difference in IFN-γ and IL-4 levels,IFN-γ / IL-4 ratio and Fe NO（ P〉0.05）. The ratio of IFN-γ / IL-4 was significantly higher in the study group than in the control group after the treatment（ P〈0.05）. The level of Fe NO decreased more significantly in the study group than in the control group（ P〈0.05）. Conclusion Aminophylline plays a certain regulatory role on Thl / Th2 balance in CVA patients,which can improve airway inflammation in patients with CVA and has a certain clinical application value.