间苯三酚与硫酸镁治疗晚期先兆性流产的不良反应对比分析

Comparative Analysis on Adverse Reactions of Phloroglucinol and Magnesium Sulfate in Treatment of Patients with Late Threatened Abortion

目的对比分析间苯三酚与硫酸镁治疗晚期先兆性流产的不良反应,为临床安全用药提供参考。方法收集本院经确诊为晚期先兆性流产的患者129例,随机分为观察组(69例)和对照组(60例),观察组采用间苯三酚治疗,对照组采用硫酸镁治疗,比较2组用药的不良反应情况、临床症状表现,并作出评价。结果间苯三酚与硫酸镁不良反应发生率分别为2.9%和26.70%,差异具有统计学意义(P<0.05),2组的疗效无显著性差异(P>0.05)。结论间苯三酚治疗晚期先兆性流产的不良反应少,孕妇耐受性好、用药依从性高,值得临床上推广应用。

OBJECTIVE To compare the adverse reactions of phloroglucinol and magnesium sulfate in patients with late threatened abortion. METHODS A total of 129 patients who with late threatened abortion were randomly assigned to the observation group（ 69 patients） and the control group（ 60 patients）. Patients in the observation group were treated by phloroglucinol,while patients in the control group were treated by magnesium Sulfate. The adverse reactions and clinical symptoms of patients in these 2groups were compared. RESULTS The incidence of adverse reactions of the observation group and the control group were 2. 9% and26. 7%（ P〈0.05）,and there were no significant differences in clinical effect between these 2 groups. CONCLUSION Phloroglucinol is an effective,less toxic with better tolerance drug,it is worthy to apply in clinical.