舒血宁联合贝那普利治疗2型糖尿病合并高血压肾损害的临床疗效观察

Effect of Shuxuening Injections Combined with Beinazepril on Type 2 Diabetes with Hypertensive Renal Damage

目的探讨舒血宁联合贝那普利治疗2型糖尿病合并高血压肾功能损害的临床疗效。方法对2012-2013年院内确诊的2型糖尿病合并高血压并有微量白蛋白尿的180例患者随机分为2组,2组均给予常规降糖治疗,对照组给予贝那普利治疗,治疗组采用舒血宁注射液联合贝那普利治疗,观察2组患者治疗前后血压和肾功能的变化。结果观察组有效率为88.89%,对照组为67.78%,差异具有统计学意义（χ^2=11.82,P〈0.05）;治疗后观察组SBP、DBP、脉压、肌酐、尿微量白蛋白（m Alb）、24 h尿蛋白等指标显著下降,与治疗前比差异具有统计学意义（P〈0.05）;观察组肌酐、尿微量白蛋白（m Alb）、24 h尿蛋白与对照组治疗后相比较,差异具有统计学意义（P〈0.05）。结论舒血宁联合贝那普利能有效改善2型糖尿病合并高血压患者的早期肾损害,延缓病情进展。

OBJECTIVE To study the clinical effect of Shuxuening injections combined with beinazepril on patients with type 2diabetes and hypertensive renal damage. METHODS A total of 180 patients were randomly divided into the treatment[U3]group and the control group,all patients were diagnose with type 2 diabetes between 2012 to 2013. Conventional treatment was given to all patients in the 2 groups. Patients in the control group were treated with beinazepril,and patients in the treatment group were treated with beinazepril combined with Shuxuening injections. After the treatment,the blood pressure and renal function changes in all patients were observed. RESULTS The effective of patients in the treatment group was 88. 89%,and that of the control group was 67. 78%; the difference was statistically significant（ χ^2= 11. 82,P〈0.05）. After treatment,the indicators of SBP,DBP,PP,creatinine,m Alb,24 h urinary protein of patients in the treatment group were lower than before（ P〈0.05）. In patients of the control group,the creatinine,m Alb,24 h urinary protein were lower than before（ P〈0.05）. CONCLUSION Combination of Shuxuening injections and beinazepril is more effective in improving early renal damage in patients with type 2 diabetes than beinazepril alone.