灵须护肝片对急性酒精性肝损伤的保护作用

Protective effect of Lingxu liver-protecting tablets on alcohol-induced liver injury

目的研究灵须护肝片对小鼠急性酒精性肝损伤的保护作用。方法以50%乙醇灌胃方法造成小鼠急性酒精性肝损伤模型,观察血清谷丙转氨酶(ALT)、谷草转氨酶(AST)、肝组织三酰甘油(TG)、丙二醛(MDA)、还原型谷胱甘肽(GSH)的水平。结果与模型对照组相比,阳性对照组、灵须护肝片中、高剂量组均可降低血清中ALT、AST的活性及肝组织中TG、MDA的含量(P<0.05),提高肝组织中GSH的含量(P<0.05)。结论灵须护肝片对小鼠急性酒精性肝损伤具有保护作用,可显著降低ALT、AST活性,升高GSH含量,调节TG、MDA含量。

Objective To investigate the protective effect of Lingxu liver-protecting tablets on alcohol-induced acute liver injury in mice. Methods The acute liver injury animal model was established in mice by 50% alcohol gavage.Activities of serum of alanine aminotransferase（ ALT）,aspartate aminotrans-ferase（ AST）,content of triglyceride（ TG）,malondialdehyde（ MDA）,glutathione（ GSH） in liver homogenate were all studied. Results Compared with the model control group,the positive control group,middle and high dosage of Lingxu liver-protecting tablets significantly decreased the activities of serum ALT and AST and the content of liver TG and MDA（ P〈 0. 05）,increased the content of liver GSH（ P〈 0. 05）. Conclusion Lingxu liver-protecting tablets showed protective effects against acute liver injury induced by alcohol in mice. It can significantly reduce the activity of ALT and AST,increase the content of GSH,and regulate the content of TG and MDA.