阿司匹林联合格列美脲对磺脲类药物继发性失效的2型糖尿病患者相关指标的影响

Effect of Aspirin Combined with Glimepiride on Related Indexes of Sulfonylureas Secondary Failure Patients with Type 2 Diabetes

目的:观察阿司匹林联合格列美脲对磺脲类药物继发性失效的2型糖尿病患者相关指标的影响。方法:将112例对磺脲类药物继发性失效的2型糖尿病患者随机均分为对照组和观察组。对照组患者给予格列美脲片2 mg,口服,每日3次;观察组患者在对照组治疗的基础上给予阿司匹林肠溶片50 mg,口服,每日2次。两组患者疗程均为2个月。观察两组患者治疗前后糖化血红蛋白(Hb A1c)、空腹血糖(FPG)、餐后2 h血糖(2 h PG)、C反应蛋白(CRP)、肿瘤坏死因子α(TNF-α)、白细胞介素6(IL-6)、餐后2 h C肽(2 h CP)、胰岛素分泌指数(Homa-β)、胰岛素抵抗指数(Homa-IR)及不良反应发生情况。结果:治疗后两组患者Hb A1c、FPG、2 h PG、CRP、TNF-α、IL-6、Homa-IR均显著低于同组治疗前,且观察组低于对照组;2 h CP、Homa-β均显著高于同组治疗前,且观察组高于对照组,差异均有统计学意义(P<0.05)。两组患者不良反应发生率比较差异无统计学意义(P>0.05)。结论:阿司匹林联合格列美脲较单用格列美脲可显著降低磺脲类药物继发性失效的2型糖尿病患者的炎性细胞因子水平,提高胰岛β细胞功能,有效控制血糖,且安全性亦较好。

OBJECTIVE：To observe the effects of aspirin combined with glimepiride on related indexes of sulfonylureas secondary failure patients with type 2 diabetes. METHODS：Totally 112 sulfonylureas secondary failure patients with type 2 diabetes were randomly divided into treatment group and control group. Patients in control group were orally given glimepiride tablets 2 mg,3 times a day. Patients in treatment group were orally given aspirin enteric coated tablets 50 mg based on the treatment of control group,twice a day. The course of both was 2 months. The clinic data was observed,including glycosylated hemoglobin（Hb A1c）,fasting plasma glucose（FPG）,2 h plasma glucose（2 h PG）,C-reaction protein（CRP）,TNF-α,interleukin-6（IL-6）,postprandial 2 h C peptide（2 h CP）,Homa-β index,Homa-IR index and adverse reaction incidence. RESULTS：After treatment,Hb A1 c,FPG,2 h PG,CRP,TNF-α,IL-6 and Homa-IR in 2 groups were significantly lower than before and observation group was lower than control group;2 h CP and Homa-β were significantly higher than before and treatment group was higher than control group,with significant differences（P〈0.05）. CONCLUSIONS：Aspirin combined with glimepiride can significantly reduce the level of inflammatory cells factors of sulfonylureas secondary failure patients with type 2 diabetes than only glimepiride. It can improve the function of pancreatic β-cell and effectively control the level of blood glucose with good safety.