艾司西酞普兰治疗慢性心力衰竭合并抑郁伴或不伴焦虑的临床观察

Clinical Observation of Escitalopram in the Treatment of Chronic Heart Failure Combined with Depression Complicated with or without Anxiety

目的:观察艾司西酞普兰治疗慢性心力衰竭(CHF)合并抑郁伴或不伴焦虑的临床疗效和安全性。方法:将50例CHF合并抑郁伴或不伴焦虑患者随机均分为对照组和观察组。对照组患者给予原发病治疗、去除CHF诱因、限制饮食、口服CHF治疗药物等常规治疗;观察组患者在对照组治疗的基础上给予艾司西酞普兰片10 mg,口服,每日1次。两组患者疗程均为6个月。观察两组患者的临床疗效、治疗前后抑郁自评量表(SDS)评分、汉密尔顿抑郁量表(HAMD)评分、左心室射血分数(LVEF)、左心室短径缩短率(FS)及不良反应发生情况。结果:治疗后观察组患者总有效率显著高于对照组,差异有统计学意义(P<0.05)。治疗后两组患者SDS评分、HAMD评分均显著低于同组治疗前,且观察组低于对照组;LVEF、FS均显著高于同组治疗前,且观察组高于对照组(P<0.05)。两组患者不良反应发生率比较差异无统计学意义(P>0.05)。结论:艾司西酞普兰可有效改善CHF合并抑郁伴或不伴焦虑患者的抑郁症状,提高心功能,且安全性较好。

OBJECTIVE：To obserre the clinical efficacy and safety of escitalopram in the treatment of chronic heart failure（CHF）combined with depression complicated with or without anxiety. METHODS：A total of 50 patients with CHF combined with depression complicated with or without anxiety were randomly divided into control group and treatment group. Patients in control group were given routine treatment,including primary disease treatment,removal of CHF incentives,avoiding of heavy physical labor,restricted diet and orally given routine CHF drugs,etc. Patients in treatment group were orally given Escitalopram tablets 10 mg based on the treatment of contrl group,once a day. The course of both was 6 months. The clinic data was observed,including efficacy,SDS,HAMD score,LVEF,FS and ADR. RESULTS：The total effective rate in treatment group was significantly higher than control group,with significant difference（P〈0.05）. After treatment,the SDS score and HAMD score in 2 groups were significantly lower than before and treatment group was lower than control group;LVEF and FS were significantly higher than before and treatment group was higher than control group（P〈0.05）. There was no significant difference in the adverse reaction incidence（P〉0.05）. CONCLUSIONS：Escitalopram can effectively improve the depression of patients in the treatment of CHF combined with depression complicated with or without anxiety and improve the heart function with good safety.