血清血管内皮生长因子及碱性成纤维细胞生长因子水平与儿童烟雾病的相关性研究

The Research of Serum Levels of Vascular Endothelial Growth Factor and Basic Fibroblast Growth Factor of Moyamoya Disease in Children

目的:探讨血清血管内皮生长因子(VEGF)和碱性成纤维细胞生长因子(b-FGF)在儿童烟雾病发病中的作用。方法:采用双抗体酶联免疫吸附法(ELISA)检测42例烟雾病患儿和40例健康儿童血清VEGF及b-FGF水平。结果:烟雾病患儿血清VEGF和b-FGF水平明显高于健康儿童,两组比较差异均有统计学意义(P<0.01);出血型烟雾病患儿血清VEGF和b-FGF水平明显高于缺血型(P<0.05);Suzuki级别与VEGF和b-FGF水平呈正相关(P<0.01);血清VEGF与b-FGF水平呈正相关(P<0.01)。结论:VEGF和b-FGF与烟雾病新生血管的发生有密切关系,血清VEGF及b-FGF水平可一定程度上反映烟雾病患儿的血管病变程度。

Objective： To investigate the role of vascular endothelial growth factor（ VEGF） and basic fibroblast growth factor（ b-FGF）in the pathogenesis of moyamoya disease. Methods： The serum levels of VEGF and b-FGF in 42 children with moyamoya disease and 40 healthy children were detected by the double antibody enzyme-linked immunosorbent（ ELISA）. Results： The serum levels of VEGF and b-FGF in children with moyamoya disease were significantly higher than that of normal control group. The serum levels of VEGF and b-FGF in hemorrhagic moyamoya children were obviously higher than that of children with ischemic type. The relations between Suzuki and VEGF levels and b-FGF levels were positively correlated. Serum levels of VEGF and b-FGF were positively correlated. Conclusion：There are close relationships between the angiogenesis and the levels of VEGF and b-FGF in children with moyamoya disease. Serum levels of VEGF and b-FGF can partly reflect the extent of vascular lesions in children with moyamoya disease.