摘要
Inhaled anticholinergic agent tiotropium is widely used in the treatment of chronic obstructive pulmonary disease（COPD）. However, it has pro-arrhythmic and pro-ischaemic effects, which can potentially increase the risk of serious cardiovascular events, especially in patients with pre-existing arrhythmias. We presented a 79-year-old man with a medical history of arrhythmia, who developed atrial fibrillation after used tiotropium 18 μg daily for two weeks. We urge the caution of pro-arrhythmic effect of tiotropium. Healthcare professionals should be aware of the potential effect when prescribing tiotropium to patients with known cardiac rhythm disorders.
吸入性抗胆碱能药物噻托溴铵广泛用于COPD的治疗。然而噻托溴铵有促心律失常促缺血作用,增加患者心血管事件的发生率。有心律失常疾病的患者,其发生率会更大。1例79岁男性患者,有心律失常病史,使用噻托溴铵粉吸入剂18μg,2次/天,2周后出现房颤,对症治疗后痊愈。噻托溴铵的促心律失常作用很容易被忽略,本文旨在提醒医务人员警惕噻托溴铵粉吸入剂在COPD患者中的促心律失常作用。
