曲唑酮联合低剂量西地那非对早泄合并勃起功能障碍患者的疗效及安全性分析

Efficacy and safety analysis of trazodone combined low dose of sildenafil treatment on patients with ED and PE

目的:观察分析曲唑酮联合低剂量西地那非对PE合并ED患者的疗效及安全性分析。方法:选取2010年3月至2011年3月收治的早泄合并勃起功能障碍的患者共87例。随机将患者分为观察组和对照组,其中观察组患者采用曲唑酮联合低剂量的西地那非;对照组患者单纯采用曲唑酮。结果:观察组和对照组两组患者接受治疗后IIEF-5的评分有明显上升,其中观察组为(19.5±2.3)分,明显高于对照组的(16.1±3.5)分;而观察组患者的LELT时间均明显要高于对照组,分别是(5.2±0.4)min和(2.9±0.1)min。观察组患者的PE治疗有效率为95.5%,明显要高于对照组的81.4%;而观察组的ED治疗有效率为93.2%,明显比对照组的79.1%要高。观察组患者的不良反应发生率为22.7%,对照组为20.9%;两组患者的血压、血肌酐、血环孢素A等指标对比没有显著性差异。结论:曲唑酮联合低剂量西地那非对PE合并ED有显著的疗效和较高安全性。

Objectives： To observe the efficacy and safety analysis of trazodone combined low dose of sildenafil treatment on patients with ED and PE. Methods： 87 patients with erectile dysfunction and premature ejaculation,from March 2010 to March 2011,were selected and randomly divided into observation group and control group. Observation group was given trazodone combined with low doses of sildenafil treatment; control group was only given trazodone treatment. Results： IIEF- 5 score of the observation group and control group increased significantly after treatment. The observation group＇s（ 19. 5 ± 2. 3） points were significantly higher than that of control group（ 16. 1 ± 3. 5）; the LELT time of observation group was significantly higher than that of control group,which were（ 5. 2 ± 0. 4） min and（ 2. 9 ± 0. 1） min respectively. Effective rate of PE treatment in observation group was95. 5%,which was significantly higher than the control group of 81. 4%; effective rate of ED treatment in observation group was 93. 2%,which was significantly higher than the control group of 79. 1%. Adverse reactions rate was22. 7% in the observation group and 20. 9% in the control group,and differences in blood pressure,serum creatinine,blood,cyclosporine A and other indicators between the two groups were not significantly significant. Conclusion： Trazodone combined low dose of sildenafil is of significantly high efficacy and safety in the treatment on patients with ED and PE.