帕金森病患者性功能障碍的发生率及危险因素分析

The incidence and risk factors of male sexual dysfunction in patients with Parkinson's disease

目的：观察男性帕金森病（PD）患者性功能障碍的发生率及危险因素。方法：选择2010年1月至2013年12月在我院治疗的帕金森病男性患者124例,统计性功能障碍发生率及年龄分布;采用卡方检验分析患者年龄、教育程度、病程、认知功能、抑郁状况、Hoenhn-Yahr分期、运动障碍严重程度、左旋多巴等效剂量等因素对性功能障碍是否存在影响;采用logistic回归分析筛选独立影响因素。结果：124例PD患者中,53例（42.74%）发生性功能障碍;38~49岁发生率最高（48.28%）;#2检验显示,汉密尔顿抑郁量表（HAMD）得分是性功能障碍的危险因素（X^2=17.742;P〈0.05）;多因素logistic回归分析显示,HAMD得分是性功能障碍的独立危险因素（OR=7.023,P〈0.05）;其他因素均与性功能障碍无明显相关。结论：PD患者性功能障碍的发生率较高;PD患者抑郁程度和性功能障碍的发生呈正相关。

Objectives： To investigate the incidence and risk factors of male sexual dysfunction in patientswith Parkinson＇s disease（ PD）. Methods： 124 male patients with PD in our hospital from Jan 2011 to Dec 2013 were enrolled and the statistical analysis was performed to analyze the incidence rate and risk factors of sexual dysfunction,including age,education,disease course,cognitive function,depression,Hoenhn- Yahr staging,movement disorder,levodopa equivalent doses and others. Results： 53（ 42. 74%） patients with sexual dysfunction were found. People from 38 to 49 years old（ 48. 28%） was the majority patients. χ^2test show that Hamilton Depression Scale（ HAMD） score was the risk factor of sexual dysfunction（ χ^2= 17. 742; P〈 0. 05）; Multivariate logistic regression analyses revealed that HAMD score was the independent risk factor for sexual dysfunction（ OR = 7. 023,P〈 0. 05）; all other factors were not correlated with sexual dysfunction of patients with PD. Conclusion： Sexual dysfunction is a common symptom in males with Parkinson＇s disease,and is correlated with the high HAMD score.