不同剂量的GnRH-a在诱导排卵中的临床效果观察

Clinical application of different doses of GnRH-a on ovulation induction

目的:探讨经阴道彩超监测小剂量GnRH方案诱导排卵的临床应用价值。方法:回顾性分析2013年至2014年中因不孕症于我院生殖医学中心分别接受1/2和1/3小剂量GnRH诱导排卵的74例患者,通过经阴道彩超了解个体对GnRH-a敏感性的差异,评价和探索不同低GnRH-a的剂量对不孕症患者诱导排卵的临床疗效。结果:1/3剂量组优质胚胎率、临床妊娠率及胚胎种植率显著高于1/2剂量组(P<0.05)。两组间GnRH总剂量、平均获卵数、受精率、卵裂率、临床妊娠率无差异(P>0.05)。结论:1/3剂量GnRH短效促排卵方案较1/2剂量组更加安全、简便、有效,经阴道彩超可以方便准确的监测小剂量GnRH-a诱导排卵的疗效。

Objectives： To investigate the clinical value of low- dose GnRH- induced ovulation monitored by transvaginal ultrasound. Methods： 74 infertility patients that received 1 /2 or 1 /3 dose of GnRH to induce ovulation from 2013 to 2014 in our hospital were included in the study. Individual sensitivity difference to GnRH- a was observed by transvaginal ultrasound,and the different clinical efficacy of low doses of GnRH- a to induce ovulationwas further evaluated and explored. Results： 1 /3 dose of GnRH were more efficacy and safer than 1 /2 dose of GnRH. There were no difference between the two groups on total dose,average number of oocytes,fertilization rate,cleavage rate,and clinical pregnancy rate. Conclusion： 1 /3 dose of GnRH is more efficacy and safer than 1 /2 dose of GnRH. Transvaginal ultrasound can accurately monitor the effect of small doses of GnRH- a to induce ovulation.