美沙酮维持治疗门诊综合干预效果评价

GENERAL INTERVENTION ON THE EFFECT OF METHADONE MAINTEANCE TREATMENT

目的:评估综合干预措施对提高美沙酮维持治疗(MMT)维持率的作用效果。方法:根据随机对照试验设计的原则,我们将美沙酮门诊符合条件的73名在服人员随机分成对照组和治疗组,对照组接受常规美沙酮维持治疗服务和基本的激励措施,干预组在接受常规美沙酮维持治疗服务和基本的激励措施的同时,还接受包括医护人员、戒毒社工及家属提供心理-社会干预服务在内的综合干预措施,分别在1个月、3个月、6个月、9个月、12个月、15个月时观察两组维持率及脱失率的情况,评价其干预效果并进行统计学分析。结果:对照组和干预组在1个月、3个月、6个月、9个月、12个月、15个月时的维持率分别为91.9%、75.7%、64.9%、56.8%、54.1%、48.6%和97.2%、91.7%、88.9%、86.1%、83.3%、77.8%,从第6个月开始,干预组的维持率明显高于对照组,两者差异有统计学意义。结论:有针对性地采取包括心理-社会干预服务在内的综合干预措施,可以提高服药人员依从性,降低脱失率,提高服药率,提高维持治疗的效果。

Objective：To evaluate general intervention on the effect of methadone maintenance treatment（MMT）. Methods：The present study used a randomized control trial design. All eligible MMT users of the MMT clinics were randomly assigned into two groups. The control group received the standard MMT service while the intervention group received the standard MMT and primary clinical management and general intervention （including psychosocial interventions） provided by clinic staff, social workers and patients family. Then we detected the retention rate and drop out rate in one - month, three - month, six- month, nine- month, twelve- month, fifteen- month to evaluate general intervention on the retention rate..Results ：The retention rate of the control group and the intervention group is 91.9%, 75. 7%, 64.9%, 56.8%, 54.1%, 48.6% and 97.2%, 91.7%, 88.9%, 86.1%, 83.3%, 77.8% in one - month, three - month, six - month, nine - month, twelve - month, fifteen - month respectively. The intervention group and control group showed significant differences after six - month. Conclusion： General intervention （including psychosocial interventions） on the effect of MMT raises the retention rates of MMT patients and reduces drop out rate.