摘要
An efficient phase-transfer-catalyzed directed reductive amination of α-keto esters was described using simple substituted benzyl amines as nitrogen source and K2CO3 as base at room temperature, giving a series of aliphatic a-amino acid derivatives in moderate to high yields(up to 99%). Preliminary study on this asymmetric process showed that cinchona-derived phase transfer catalyst was elTective, aflbrding the corresponding product in 13% e.e. and 40% yield.
An efficient phase-transfer-catalyzed directed reductive amination of α-keto esters was described using simple substituted benzyl amines as nitrogen source and K2CO3 as base at room temperature, giving a series of aliphatic a-amino acid derivatives in moderate to high yields(up to 99%). Preliminary study on this asymmetric process showed that cinchona-derived phase transfer catalyst was elTective, aflbrding the corresponding product in 13% e.e. and 40% yield.
基金
Supported by the Natural Science Foundation of China(No.21402127). Foundation of Liaoning Province Education Department(No.l,2013381), PhD Research Startup Foundation of Liaoning Province(No.20131110), and Career Dcvclopment Support Plan for Young and Middle-aged Teachers in Shenyang Pharmaceutical University.